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UnknownMolecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas.
Not available
S-EPMC6105278 | biostudies-literature
UnknownElevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors.
Not available
S-EPMC8455074 | biostudies-literature
UnknownTargeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas.
Not available
S-EPMC8762577 | biostudies-literature
ProteomicsMetabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma
PFA ependymomas are a lethal glial malignancy of the hindbrain found in babies and toddlers. Lacking any highly recurrent somatic mutations, PFAs have been proposed as a largely epigenetically driven tumor type. An almost complete lack of model systems has inhibited discovery of novel PFA therapies....
ORGANISM(S): Homo sapiens (Human) 
2020-08-13 | PXD018191 | Pride
Proteomics H3k27 methylation and acetylation Pfa ependymomas 
GenomicsClinically relevant molecular hallmarks of PFA ependymomas display intratumoral heterogeneity and correlate with tumor morphology
Clinically relevant molecular hallmarks of PFA ependymomas display intratumoral heterogeneity and correlate with tumor morphology
PRJNA1045254 | ENA
GenomicsPFA ependymoma cancer study
Sequencing data related the PFA ependymoma study (Michealraj et al., Cell 2020), a lethal glial malignancy of the hindbrain found in babies and toddlers.
EGAS00001004312 | EGA
TranscriptomicsGene expression data from posterior fossa ependymomas
We have discovered two major molecular subgroups of PFA molecular group posterior fossa ependymomas by DNA methylation profiling. These are also distinguished by gene expression profiling using Affymetrix U133v2 arrays with correspondence to data generated by DNA methylation profiling.
ORGANISM(S): Homo sapiens 
2018-08-03 | GSE100240 | GEO
UnknownClinically relevant molecular hallmarks of PFA ependymomas display intratumoral heterogeneity and correlate with tumor morphology.
Not available
S-EPMC10808473 | biostudies-literature
TranscriptomicsEZHIP / CXorf67 mimics oncohistones to inhibit PRC2 in PFA ependymoma
Expression of CXorf67 is an oncogenic mechanism that drives H3K27 hypomethylation in PFA ependymomas by mimicking K27M mutated oncohistones. Background: Posterior fossa A (PFA) ependymomas comprise one out of nine molecular groups of ependymoma. PFA tumors are mainly diagnosed in infants and young c...
ORGANISM(S): Homo sapiens 
2022-03-06 | GSE127941 | GEO
UnknownEpendymomas in infancy: underlying genetic alterations, histological features, and clinical outcome.
Not available
S-EPMC7575464 | biostudies-literature
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