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TranscriptomicsMERVL/Zscan4 network activation results in transient genome-wide DNA demethylation of mESCs
Several previous studies have noted a rare sub-population of murine Embryonic Stem Cells (mESCs) which seem to express genes otherwise specific to the 2-cell stage of embryonic development. Here we sorted single cells from a MERVL/Zscan4 reporter line to investigate the continuum of expression as ce...
ORGANISM(S): Mus musculus 
2016-09-30 | E-MTAB-5058 | biostudies-arrayexpress
TranscriptomicsLoss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure [RNA-seq]
We investigated microRNA expression in motoneurons by performing small RNA sequencing of fluorescence-activated cell sorting (FACS)-isolated motoneurons labelled with the Hb9:gfp transgenic reporter and Hb9:gfp negative non-motoneurons including spinal interneurons. We find that one microRNA, micro...
ORGANISM(S): Mus musculus 
2015-12-18 | E-GEOD-75599 | biostudies-arrayexpress
TranscriptomicsLoss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure [miRNA-seq]
We investigated microRNA expression in motoneurons by performing small RNA sequencing of fluorescence-activated cell sorting (FACS)-isolated motoneurons labelled with the Hb9:gfp transgenic reporter and Hb9:gfp negative non-motoneurons including spinal interneurons. We find that one microRNA, micro...
ORGANISM(S): Mus musculus 
2015-12-18 | E-GEOD-75600 | biostudies-arrayexpress
GenomicsTRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells
TRIM28 (KAP1 - KRAB-associated protein 1) is critical for the silencing of endogenous retroviruses (ERVs) in embryonic stem (ES) cells. Here, we reveal that an essential impact of this process is the protection of cellular gene expression in early embryos from perturbation by cis-acting activators c...
ORGANISM(S): Mus musculus 
2012-12-04 | E-GEOD-41903 | biostudies-arrayexpress
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