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TranscriptomicssnRNA-seq of cortices from a MCT8-OATP1C1-deficient Allan-Herndon-Dudley Syndrome mouse model
Allan-Herndon-Dudley syndrome (AHDS) is a rare disorder caused by faulty thyroid hormone transport to the brain, leading to severe movement problems and intellectual disability. Our study in a murine model of the AHDS used snRNAseq to gain deep insights into individual cortical cells, aiming to unra...
ORGANISM(S): Mus musculus 
2026-08-07 | E-MTAB-16567 | biostudies-arrayexpress
TranscriptomicsTime‑Resolved Regulatory Architecture of Leptin Signaling: Early and Late Transcription Factor Activity and Pathway Interactions
Background: Leptin is a master regulator of energy homeostasis, acting through its long‑form receptor LepRb to modulate neuronal activity, transcriptional programs, and metabolic pathways that control feeding and body‑weight regulation. While classical work established JAK2–STAT3 signaling as a cent...
ORGANISM(S): Mus musculus 
2026-10-29 | E-MTAB-16711 | biostudies-arrayexpress
TranscriptomicsAffymetrix GeneChip Mouse Gene 1.0 arrays of RNA extracted from gastrocnemius muscle of 4 global Ppp3cb KO mice and 4 corresponding WT littermates, and 4 skeletal muscle-specific Ppp3r1Mlc1fCre KO and 4 corresponding WT littermates.
Global deficiency of catalytic subunit Ppp3cb, and tissue-specific ablation of regulatory subunit Ppp3r1 from skeletal muscle but not adipose tissue or liver led to protection from high-fat diet induced obesity and comorbid sequelæ. Ser637 hyperphosphorylation of dynamin-related protein 1 (Drp1) in ...
ORGANISM(S): Mus musculus 
2015-07-22 | E-GEOD-71174 | biostudies-arrayexpress
UnknownPrognosis and quality of life in patients with locally advanced rectal cancer after abdominoperineal resection in the CAO/ARO/AIO-04 randomized phase 3 trial.
Not available
S-EPMC11825916 | biostudies-literature
UnknownTwo phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
Not available
S-EPMC4159618 | biostudies-literature
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