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ProteomicsBiotin-pgRNAWT or Biotin-pgRNAAUUUA to AUCUC RNA pulldown LC-MS/MS
The nuclear export of HBV RNAs allows the virus to synthesize its proteins through the translation machinery and replicate its genome through reverse transcription in the cytoplasm. However, the molecular mechanisms underlying this important process remain largely obscure. To illustrate this process...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD044015 | Pride
Rna nuclear export Pgrna binding proteins Rna stability Au rich element Hbv rna 
Genomicsac4C stabilizes a G-quadruplex to enforce HBV pgRNA clearance
ac4C stabilizes a G-quadruplex to enforce HBV pgRNA clearance
PRJNA1464515 | ENA
Otherac4C stabilizes a G-quadruplex to enforce HBV pgRNA clearance
Hepatitis B virus (HBV) pregenomic RNA (pgRNA) is essential for viral replication, but the host factors that degrade it remain poorly understood. Using ac4C-RIP-seq, CLIP-seq, and RedaC:T-amplicon sequencing, we identify an N4-acetylcytidine (ac4C) RNA modification-dependent pathway that targets HBV...
ORGANISM(S): Mus musculus Homo sapiens 
2026-05-13 | GSE330506 | GEO
UnknownRNA binding protein TIAR modulates HBV replication by tipping the balance of pgRNA translation.
Not available
S-EPMC10497612 | biostudies-literature
GenomicsCRISPR-Cas9 screening of lncRNAs and protein coding genes involved in the transdifferentiation from human pre-B cells into macrophages
BLaER1 cells are human leukemia pre-B cells able to transdifferentiate into functional and non-tumorigenic macrophages. With the goal of uncovering the genes involved in the transdifferentiation process, we have designed a DECKO (Double Excision CRISPR Knockout) library to knockout lncRNAs and prote...
ORGANISM(S): Homo sapiens 
2022-04-25 | E-MTAB-10445 | biostudies-arrayexpress
UnknownC-terminal substitution of HBV core proteins with those from DHBV reveals that arginine-rich 167RRRSQSPRR175 domain is critical for HBV replication.
Not available
S-EPMC3401125 | biostudies-literature
UnknownNEDD4-binding protein 1 suppresses hepatitis B virus replication by regulating viral RNAs.
Not available
S-EPMC12282332 | biostudies-literature
UnknownThe interface between hepatitis B virus capsid proteins affects self-assembly, pregenomic RNA packaging, and reverse transcription.
Not available
S-EPMC4337549 | biostudies-literature
UnknownStructural insights of the conserved "priming loop" of hepatitis B virus pre-genomic RNA.
Not available
S-EPMC10167916 | biostudies-literature
UnknownInterferon-inducible ribonuclease ISG20 inhibits hepatitis B virus replication through directly binding to the epsilon stem-loop structure of viral RNA.
Not available
S-EPMC5388505 | biostudies-literature
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