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ProteomicsExperimental strategies to improve drug-target identification in mass spectrometry-based thermal stability assays
In this study, we developed a model system for the assessment of small molecule-protein interactions using intact cells treated with a commercially available highly specific mitogen-activated protein kinase (MEK) 1/2 inhibitor to prepare a set of unfractionated test samples labeled with tandem mass ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD034087 | Pride
Cetsa Mass spectrometry Tpp Target identification Thermal stability assays Drug-protein interactions 
ProteomicsExperimental strategies to improve drug-target identification in mass spectrometry-based thermal stability assays
Mass spectrometry (MS)-based thermal stability assays have recently emerged as one of the most promising solutions for the identification of protein-ligand interactions. Here, we have investigated eight combinations of several recently introduced MS-based advancements, including the Phase-Constraine...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD040284 | Pride
Cetsa Mass spectrometry Tpp Target identification Thermal stability assays Drug-protein interactions 
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