Pharmacological effect

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Unknown (10426)
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Organisms

Homo sapiens (392)
Mus musculus (327)
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unidentified (2)
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Mus musculus domesticus (1)
Streptomyces coelicolor (1)

Organisms

Homo sapiens (228)
Mus musculus (220)
Rattus norvegicus (15)
Drosophila melanogaster (7)
Danio rerio (4)
Caenorhabditis elegans (3)
Canis lupus familiaris (2)
Saccharomyces cerevisiae (2)
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Apis mellifera ligustica (1)
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Aspergillus fumigatus (1)
Apis mellifera (1)
Mus (1)
Arabidopsis (1)
Homo (1)
human oral metagenome (1)
gut metagenome (1)
Mycobacterium tuberculosis (1)
Arabidopsis thaliana (1)
unidentified (1)

Repository

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geo (429)
biostudies-arrayexpress (397)
pride (73)
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ExpressionAtlas (1)
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Tissue

Cell culture (28)
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Heart (5)
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Acute lymphoblastic leukemia cell line (1)
Aorta thoracica (1)
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Disease

Breast cancer (5)
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Type 2 diabetes mellitus (2)
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Polycythemia due to hypoxia (1)
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Amyotrophic lateral sclerosis type 1 (1)
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Depression (1)
Diarrhea (1)
Duchenne muscular dystrophy (1)
Fragile X syndrome (1)
Glioblastoma (1)
Heart failure (1)

Technology Type

Mass Spectrometry (73)
Shotgun proteomics (36)
Mass spectrometry (19)
Bottom-up proteomics (18)
Mass spectrometry assay (17)
Data-dependent acquisition (12)
Data-independent acquisition (10)
Affinity purification coupled with mass spectrometry proteomics (4)
SWATH MS (4)
Top-down proteomics (4)
NextSeq 550, ILLUMINA (1)
Illumina 1.2M, Affymetrix 6.0, Affymetrix 6.0 - CHIAMO (1)
NMR spectroscopy (1)
Affinity proteomics (1)
DiaPASEF (1)
Gel-based experiment (1)
HDMSE (1)

Instrument Platform

Liquid Chromatography MS - negative - reverse phase (10)
Liquid Chromatography MS - positive - reverse phase (9)
Illumina NovaSeq 6000 (8)
Liquid Chromatography MS - negative - reverse-phase (7)
Illumina HiSeq 2500 (5)
Illumina HiSeq 2000 (3)
Illumina HiSeq 4000 (3)
NextSeq 500 (3)
LTQ Orbitrap Velos (3)
Illumina NovaSeq X (2)
DNBSEQ-G400 (2)
Illumina MiSeq (2)
Q Exactive (2)
Affymetrix GCS 3000 (1)
GeneChip® Pico Kit (Affymetrix) (1)
Affymetrix Clariom™ S (400 Format) (1)
Applied Biosciences (1)
The Agilent C scanner (1)
None (1)
Axon GenePix 4000B scanning hardware (1)
None (1)
Illumina HiSeq X (1)
LTQ Orbitrap Elite (1)
Orbitrap Fusion (1)
Orbitrap Fusion Lumos (1)
Q Exactive HF (1)
Q Exactive HF-X (1)
Synapt G2 HDMS (1)
TripleTOF 5600 (1)
ZenoTOF 7600 (1)

Publication Date

2025 (127)
2026 (99)
2024 (87)
2023 (70)
2013 (60)
2014 (53)
2010 (52)
2012 (50)
2016 (48)
2022 (46)
2015 (43)
2021 (42)
2011 (36)
2020 (35)
2008 (34)
2007 (24)
2009 (18)
2019 (16)
2017 (16)
2018 (13)
2005 (3)
2006 (3)
2004 (3)

UNIPROT ID/AC

O00519 (1)
Q9NTU9 (1)
Q3T1B0 (1)
Q9NWT6 (1)
P16157 (1)
Q9Y2N7 (1)
Q99814 (1)
Q16665 (1)

CHEBI ID

CHEBI:30769 (7)
CHEBI:18237 (6)
CHEBI:22653 (6)
CHEBI:28300 (6)
CHEBI:16870 (6)
CHEBI:15741 (6)
CHEBI:7916 (6)
CHEBI:15891 (6)
CHEBI:16704 (6)
CHEBI:18012 (6)
CHEBI:16027 (6)
CHEBI:30915 (6)
CHEBI:16919 (6)
CHEBI:24266 (5)
CHEBI:17822 (5)
CHEBI:26271 (5)
CHEBI:22660 (5)
CHEBI:18186 (5)
CHEBI:16811 (5)
CHEBI:16708 (5)
CHEBI:16750 (5)
CHEBI:64033 (1)
CHEBI:64032 (1)
CHEBI:71464 (1)
CHEBI:71466 (1)
CHEBI:32635 (1)
CHEBI:46195 (1)
CHEBI:2700 (1)
CHEBI:15379 (1)
CHEBI:29108 (1)

Metabolite Name

Taurine (9)
Uridine (8)
Inosine (8)
Asparagine (7)
Adenine (7)
Tryptophan (7)
Citrulline (6)
Methionine (6)
Lysine (6)
Tyrosine (6)
Serine (6)
Phenylalanine (6)
Glutamine (6)
Creatine (6)
4-Nitrophenol (5)
Uracil (5)
Threonine (5)
NADH (5)
Citrate (5)
Guanosine (5)
Creatinine (5)
Glycerophosphocholine (5)
Histidine (4)
Glutamate (4)
Leucine (4)
Aspartate (4)
IMP (4)
Valine (4)
GMP (4)
Kynurenine (4)

First Public Date

2025 (117)
2024 (104)
2026 (99)
2023 (68)
2020 (42)
2021 (41)
2022 (38)
2014 (36)
2019 (20)
2017 (12)
2018 (11)
2015 (11)
2016 (6)
2013 (2)

Modelling Approach

Ordinary differential equation model (5)

Study status

Completed (3)
Active, not recruiting (1)
Not provided (1)
Recruiting (1)

Lab affiliation

Inserm U1016, Institut Cochin, 24 rue du Faubourg Saint-Jacques, 75014 PARIS, FRANCE. (2)
1 National Centre for Scientific Research “Demokritos”, Agia Paraskevi, Attica, Greece 2 Department of Chemistry, National and Kapodistrian University of Athens, Greece (1)
1) Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Switzerland 2) Faculty of Science, University of Zurich, Zurich, Switzerland (1)
Associate Professor of Pharmacology Dept of Medical Biotechnology and Translational Medicine Università degli Studi di Milano (1)
Associate Professor, Neuroscience, The Scripps Research Institute Florida (1)
Baylor College of Medicine (1)
Bio-organic Chemistry Lab, Department of Pharmacy, University of Salerno, via Giovanni Paolo II 132, 84084 Fisciano, Italy (1)
CNRS UMR3348, Institut Curie, Bâtiment 110, Centre Universitaire, 91405 Orsay, France. Phone: 33-1-69863016; Fax: 33-1-69869429 (1)
Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK (1)
Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK (1)
Cancer Signaling and Epigenetics Program, Fox Chase Cancer Center, Phialdelphia, PA, USA (1)
Central Institute for Translational Cancer Research (TranslaTUM) Radiation Immuno-Oncology Group, Klinikum rechts der Isar (1)
Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK (1)
Centre for Genomics and Computational Biology Barts Cancer Institute Queen Mary University of London (1)
Charles Perkins Centre, University of Sydney (1)
Department of Biochemistry and Molecular Biology University of Southern Denmark Campusvej 55 DK-5230 Odense M Denmark (1)
Department of Glycobiology, Institute of Chemistry, Slovak Academy of Sciences (1)
Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, RWTH Aachen University Medical School, Aachen, Germany, (1)
Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, USA (1)
Department of Medicine, Nephrology and Pharmacological Sciences, Icahn School of Medicine at Mount Sinai (1)
Department of Neurobiology, Harvard Medical School; Boston, USA. (1)
Department of Pediatrics, UMCG/RUG, Groningen, The Netherlands (1)
Department of Pharmacology and Neuroscience (1)
Dept. of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill (1)
Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands (1)
Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17 177 Stockholm, Sweden SciLIfeLab, SE-17 177 Stockholm, Sweden Department of Pharmacological & Technological Chemistry, I.M. Sechenov First Moscow State Medical University, Moscow, 119146, Russia (1)
Epithelial Plasticity and Metastasis Group, Instituto de Investigación Biomédica de A Coruña (INIBIC) (1)
German Cancer Research Center (DKFZ), Heidelberg, Germany Heidelberg University, Medical Faculty, Heidelberg, Germany (1)
Head of Proteomics & Metabolomics core (1)
Inserm, CESP, Equipe « Moods » Université Paris Saclay - Batiment Henri Moissan 19 avenue des Sciences 91400 Orsay France (1)

Keyword

Actigraphy (1)
Major Depression Inventory (MDI) (1)
Insomnia Severity Index (ISI) (1)
Lycopene (1)
Anti EGFR therapy (1)
Vitamin D3 (1)
Colorectal cancer, Peripheral Neuropathies,Nursing (1)
Rectal cancer (1)
Cholecalciferol (1)
Vitamin D (1)

IsPrivate

False (5)

Classification

fungi (1)
bacteria (1)

Modification

2x(15)N labeled L-lysine (1)
4x(15)N labeled L-arginine (1)
6x(2)H labeled dimethylated L-arginine (1)

Study type

Transcription profiling by array (307)
RNA-seq of coding RNA (38)
Unknown experiment type (16)
Interventional (5)
ChIP-seq (4)
Methylation profiling by array (4)
Cell line - High-throughput sequencing (3)
RNA-seq of non coding RNA (3)
Genotyping by array (2)
Comparative genomic hybridization by array (2)
MicroRNA profiling by array (2)
DNA-seq (2)
Proteomic profiling by array (2)
RNA-seq of coding RNA from single cells (2)
RNA-seq of total RNA (2)
ChIP-chip by tiling array (1)
Translation profiling (1)
Transcription profiling by RT-PCR (1)
Other (1)
Single nucleus RNA sequencing (1)
Observational patient registry (1)

Release Date

2022 (1455)
2023 (1188)
2021 (1146)
2025 (1034)
2020 (940)
2024 (910)
2019 (737)
2018 (552)
2017 (488)
2016 (435)
2015 (373)
2014 (343)
2013 (255)
2012 (205)
2011 (183)
2010 (144)
2026 (137)
2009 (79)
2008 (79)
2007 (46)
2006 (29)
2005 (19)
2004 (14)
2003 (10)
2001 (7)
1999 (5)
2000 (4)
1997 (3)
2002 (1)
1998 (1)

Location

Iran (1)
Denmark (1)
Turkey (1)
Italy (1)
Canada (1)
France (1)

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Research on the quality markers of antioxidant activity of Kai-Xin-San based on spectrum-effect relationship

Kai-Xin-San (KXS) is one of the classic famous traditional Chinese medicine prescriptions for amnesia, which has been applied for thousands of years. Modern pharmacological research has found that KXS has significant therapeutic efficacy on nervous system diseases, which is related to its antioxidan...

2023-12-21 | MTBLS8806 | MetaboLights

Gene expression profiling in hepatic tissue of newly weaned pigs fed pharmacological zinc supplemented diets

Zinc (Zn) is an essential trace element for all life forms. Zn supplementation has been used to treat diarrheal disease in children, and in the U.S. swine industry at pharmacological levels to promote growth and fecal consistency, but underlying mechanisms explaining these beneficial effects remain ...

ORGANISM(S): Sus scrofa

2008-10-02 | E-GEOD-11972 | biostudies-arrayexpress

Effect of pharmacological inhibition of ASBT on bile composition and sclerosing cholangitis in mdr2 knockout mice

We report the effect of a potent pharmacological inhibition of ASBT in mdr2 -/- mice, compared to genetic and treatment controls using RNA-sequencing. Through quantification of mRNA in liver samples, we found significant upregulation of anti-inflammatory and anti-fibrotic gene signatures in mdr2-/-...

ORGANISM(S): Mus musculus

2016-02-17 | E-GEOD-66231 | biostudies-arrayexpress

Therapeutic Effect of Modified Meridian-Guided Acupoint Pressing on Lumbar Facet Joint Osteoarthritis: An Integrated Microbiomics and Metabolomics Analysis

Lumbar facet joint osteoarthritis (LFJ OA) is a leading cause of chronic low back pain, with limited effective long-term treatments due to the side effects of pharmacological interventions. Modified Meridian-Guided Acupoint Pressing (MMGAP), a Traditional Chinese Medicine (TCM) physical therapy, has...

2026-06-22 | MTBLS14816 | MetaboLights

The Pharmacological Effect and Mechanism of Lanthanum Hydroxide on Vascular Calcification Caused by Chronic Renal Failure Hyperphosphatemia

Objective: To investigate the treatment and mechanism of lanthanum hydroxide on hyperphosphate-induced vascular calcification in chronic renal failure. Methods: Develop a rat model of CKD hyperphosphatemia. Rats were randomly allocated to the model, lanthanum hydroxide, lanthanum carbonate, Calcium...

ORGANISM(S): Rattus norvegicus (Rat)

2021-09-09 | PXD023081 | Pride

Functional effect of DOT1L pharmacological inhibition in ERα-positive Ovarian Cancer cells

PRJEB33748 | ENA

Effect of pharmacological inhibition of SMYD3 on gene expression in patient-derived CRC-SCs

PRJNA1101506 | ENA

Unique pharmacological actions of atypical neuroleptic quetiapine: possible role in cell cycle/fate control

Quetiapine is an atypical neuroleptic with a pharmacological profile distinct from classic neuroleptics. It is currently approved for treating patients with schizophrenia, major depression and bipolar I disorder. However, its cellular effects remain elusive. We used microarrays to characterize RNA t...

ORGANISM(S): Mus musculus

2013-04-16 | E-GEOD-45229 | biostudies-arrayexpress

Effect of pharmacological BCL-2 inhibition with venetoclax on T cell homeostasis

PRJNA929527 | ENA

Pharmacological properties of baicalin on liver diseases: a narrative review.

Not available

S-EPMC8460515 | biostudies-literature

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