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GenomicsInhibition of PHB2/PINK1-mediated mitophagy in Acute Myeloid Leukemia
Inhibition of PHB2/PINK1-mediated mitophagy in Acute Myeloid Leukemia
PRJNA1309098 | ENA
TranscriptomicsInhibition of PHB2/PINK1-mediated mitophagy in Acute Myeloid Leukemia
Acute myeloid leukemia (AML) cells are highly dependent on mitochondrial activity for survival, with this metabolic reliance driven in part by BCL-2, which is therapeutically targeted by venetoclax-based therapies. The regulation of mitochondrial dynamics in leukemic cells is therefore essential for...
ORGANISM(S): Homo sapiens 
2026-09-30 | GSE306084 | GEO
UnknownGOLPH3 promotes glioma progression by enhancing PHB2-mediated autophagy.
Not available
S-EPMC8167689 | biostudies-literature
TranscriptomicsEffect of Phb2 depletion in retinal photoreceptors on gene expression in the bulk retina of C57BL/6J mice
To explore the functions for Phb2 gene in early retinal degeneration, we performed RNA-seq analysis on the bulk retinas from control and photoreceptor-specific knockout Phb2 mice at 6 weeks of age. Compared with control mice, there were 778 differentially expressed genes (log2 |fold change|> 1, log1...
ORGANISM(S): Mus musculus 
2024-12-31 | GSE246802 | GEO
UnknownPHB2 promotes tumorigenesis via RACK1 in non-small cell lung cancer.
Not available
S-EPMC7847695 | biostudies-literature
GenomicsEffect of Phb2 depletion in retinal photoreceptors on gene expression in the bulk retina of C57BL/6J mice
Effect of Phb2 depletion in retinal photoreceptors on gene expression in the bulk retina of C57BL/6J mice
PRJNA1034631 | ENA
TranscriptomicsRNA-seq transcriptonal profiling in human primary adult erythroid progenitor cells (ProEs) after shRNA-mediated depletion of TFAM and PHB2 expression
The developing erythroid cells require highly coordinated gene expression and metabolism. By comparing the proteomic and transcriptomic changes in human hematopoietic stem/progenitor cells (HSPCs) and lineage-committed erythroid progenitors (ProEs), and uncover pathways related to mitochondrial biog...
ORGANISM(S): Homo sapiens 
2017-05-15 | GSE86910 | GEO
UnknownPHB2 alleviates retinal pigment epithelium cell fibrosis by suppressing the AGE-RAGE pathway.
Not available
S-EPMC11538926 | biostudies-literature
TranscriptomicsDevelopment of chemically modified peptide targeting BIG3-PHB2 interaction on estrogen-dependent breast cancer
Our previous studies demonstrated that specific inhibition of the BIG3-PHB2 complex, which is indispensable for estrogen (E2)-signaling activation, using ERAP, a dominant-negative peptide inhibitor, leads to the suppression of E2-dependent breast cancer cell growth in vitro and in vivo. However, dur...
ORGANISM(S): Homo sapiens 
2017-06-09 | GSE87378 | GEO
GenomicsAURKA/PHB2 signaling drives acquired resistance to KRAS G12C inhibitors in KRAS G12C -mutant NSCLC
AURKA/PHB2 signaling drives acquired resistance to KRAS G12C inhibitors in KRAS G12C -mutant NSCLC
PRJNA1404127 | ENA
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