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MetabolomicsCysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis
Nephropathic cystinosis is a severe monogenic kidney disorder caused by mutations in CTNS, encoding the lysosomal transporter cystinosin, resulting in lysosomal cystine accumulation. The sole treatment, cysteamine, slows down the disease progression, but does not correct the established renal proxim...
2021-06-24 | MTBLS2538 | MetaboLights
GenomicsVascular smooth muscle cell phenotype switching during cancer progression.
Vascular smooth muscle cell phenotype switching during cancer progression.
PRJNA1094965 | ENA
TranscriptomicsExpression profiling of budding cells in colorectal cancer suggests an EMT-like phenotype and molecular subtype switching
Tumour buds undergo phenotype switching while detaching from the main tumour, as they acquire more migratory characteristics and tend to stop proliferating. Simultaneously, an EMT-like signature is observed in the tumour buds under the form of active WNT, TGF and receptor tyrosine kinase signalling....
ORGANISM(S): Homo sapiens 
2017-02-04 | E-MTAB-4065 | biostudies-arrayexpress
GenomicsDystrophin Deficiency Derives Phenotype Switching in Vascular Smooth Muscle Cells
Dystrophin Deficiency Derives Phenotype Switching in Vascular Smooth Muscle Cells
PRJNA971232 | ENA
GenomicsHierarchy of TGFβ/SMAD, Hippo/YAP/TAZ and Wnt/β-catenin signaling in melanoma phenotype switching
Hierarchy of TGFβ/SMAD, Hippo/YAP/TAZ and Wnt/β-catenin signaling in melanoma phenotype switching
PRJNA778984 | ENA
TranscriptomicsOntogenic changes in hematopoietic hierarchy determine pediatric specificity and disease phenotype in fusion oncogene-driven myeloid leukemia - scRNAseq - 2
Paediatric cancers present specific genetic alterations, however the principles underlying their differences to adult cancers are yet unclear. Poor prognosis paediatric myeloid leukaemia fusion oncogenes represent clinically-relevant models to investigate age-specific tumorigenesis. Here, we establi...
ORGANISM(S): Mus musculus 
2019-10-15 | E-MTAB-8360 | biostudies-arrayexpress
GenomicsThe core cellular network modulates immune phenotype switching in hepatitis B
The core cellular network modulates immune phenotype switching in hepatitis B
PRJNA1194020 | ENA
GenomicsMolecular reprogramming and phenotype switching in Staphylococcus aureus
Molecular reprogramming and phenotype switching in Staphylococcus aureus lead to high antibiotic persistence and affect therapy success
PRJEB37630 | ENA
GenomicsEffect of nimodipine on gene expression during TGF-β induced fibrotic phenotype switching of human orbital fibroblasts
Effect of nimodipine on gene expression during TGF-β induced fibrotic phenotype switching of human orbital fibroblasts
PRJNA916683 | ENA
GenomicsExpression profiling of budding cells in colorectal cancer suggests an EMT-like phenotype and molecular subtype switching
Expression profiling of budding cells in colorectal cancer suggests an EMT-like phenotype and molecular subtype switching
PRJEB11806 | ENA
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