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MetabolomicsMetabolome variability for two Mediterranean sponge species of the genus Haliclona: specificity, time, and space

INTRODUCTION: The study of natural variation of metabolites brings valuable information on the physiological state of the organisms as well as their phenotypic traits. In marine organisms, metabolome variability has mostly been addressed through targeted studies on metabolites of...

2021-10-27 | MTBLS638 | MetaboLights
MetabolomicsUntargeted metabolomics to understand the basis of phenotypic differences in amphotericin B-resistant Leishmania parasites

BACKGROUND: Protozoan Leishmania parasites are responsible for a range of clinical infections that represent a substantial challenge for global health. Amphotericin B (AmB) is increasingly used to treat Leishmania infection, so understanding the potential for resistance to this d...

2019-09-26 | MTBLS1167 | MetaboLights
GenomicsTunable phenotypic variability through an autoregulatory alternative sigma factor circuit
Tunable phenotypic variability through an autoregulatory alternative sigma factor circuit
PRJNA720823 | ENA
TranscriptomicsTunable phenotypic variability through an autoregulatory alternative sigma factor circuit
Genetically identical individuals in bacterial populations can display significant phenotypic variability. This variability can be functional, for example by allowing a fraction of stress prepared cells to survive an otherwise lethal stress. The optimal fraction of stress prepared cells depends on e...
ORGANISM(S): Bacillus subtilis PY79 
2021-04-10 | GSE171761 | GEO
GenomicsGenomic basis of phenotypic variability of complex disorders
Genomic basis of phenotypic variability of complex disorders
PRJNA734669 | ENA
GenomicsGenomic basis of phenotypic variability of complex disorders
Genomic basis of phenotypic variability of complex disorders
PRJNA734670 | ENA
GenomicsThe role of osteoblasts in phenotypic variability of dominant osteogenesis imperfecta: evidence from patients and murine models
The role of osteoblasts in phenotypic variability of dominant osteogenesis imperfecta: evidence from patients and murine models
PRJNA1380921 | ENA
GenomicsThe role of osteoblasts in phenotypic variability of dominant osteogenesis imperfecta: evidence from patients and murine models
The role of osteoblasts in phenotypic variability of dominant osteogenesis imperfecta: evidence from patients and murine models
PRJNA1380922 | ENA
TranscriptomicsSmall RNA-seq analysis of circulating miRNAs to identify phenotypic variability in Friedreich's ataxia patients
Friedreich’s ataxia (FRDA; OMIM 229300), an autosomal recessive neurodegenerative mitochondrial disease, is the most prevalent hereditary ataxia. In addition, FRDA patients showed additional non-neurological features such as scoliosis, diabetes and cardiac complications. Hypertrophic cardiomyopathy,...
ORGANISM(S): Homo sapiens 
2017-10-18 | E-GEOD-105052 | biostudies-arrayexpress
ProteomicsCombined Tissue-Fluid Proteomics to Unravel Phenotypic Variability in Amyotrophic Lateral Sclerosis
The lack of biomarkers for early diagnosis, clinical stratification and to monitor treatment response has hampered the development of new therapies for amyotrophic lateral sclerosis (ALS), a clinically heterogeneous neurodegenerative disorder with a variable site of disease initiation and rate of pr...
ORGANISM(S): Homo sapiens (Human) 
2020-07-30 | PXD020493 | Pride
Pbmc Als Tmt Tmtcalibrator 
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