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GenomicsThe mental retardation gene PHF8 mediates histone H4K20/H3K9 demethylation and regulates zebrafish brain apoptosis and craniofacial development: ChIP-Seq analysis
PHF8 (PHD Finger 8) mutations have been found in patients with X-linked mental retardation (XLMR) and craniofacial deformities. Here we identify PHF8 as the first enzyme that mediates demethylation of mono-methylated histone H4 lysine (K) 20 (H4K20me1), with additional activities towards H3K9me2/1 a...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-21108 | biostudies-arrayexpress
GenomicsGenome-wide mapping of H3K4me3 and of PHF8 and ZNF711 binding sites in SH-SY5Y cells
We analyzed the genome wide binding sites for the potential XLMR genes PHF8 and ZNF711 in the neuroblastoma cell line SH-SY5Y using antibodies specific for PHF8 and ZNF711 and correlated this with binding pattern of H3K4me3. The total number of peaks detected for PHF8 based on 9.8 million sequence...
ORGANISM(S): Homo sapiens 
2010-03-08 | E-GEOD-20673 | biostudies-arrayexpress
TranscriptomicsThe mental retardation gene PHF8 mediates histone H4K20/H3K9 demethylation and regulates zebrafish brain apoptosis and craniofacial development: expression analysis
PHF8 (PHD Finger 8) mutations have been found in patients with X-linked mental retardation (XLMR) and craniofacial deformities. Here we identify PHF8 as the first enzyme that mediates demethylation of mono-methylated histone H4 lysine (K) 20 (H4K20me1), with additional activities towards H3K9me2/1 a...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-21555 | biostudies-arrayexpress
TranscriptomicsKnockdown of PHF8 in HeLa S3 cells
PHF8 is an H3K9me2 demethylase, interacts with H3K4me3 and RNA Polymerase II, is enriched at thousands of transcription start sites and can act as a transcriptional co-activator. In the following experiment we wanted to analyze the impact of PHF8-knockdown on transcript levels in HeLa cells. Three i...
ORGANISM(S): Homo sapiens 
2010-05-07 | E-GEOD-20563 | biostudies-arrayexpress
GenomicsPHF8 targets histone methylation and RNA polymerase II to activate transcription
Mutations in PHF8 are associated with X-linked mental retardationand cleft lip/cleft palate. PHF8 contains a plant homeodomain(PHD) in its N-terminus and is member of a family of JmjC-domaincontaining proteins. While PHDs can act as methyl lysine recognitionmotifs, JmjC-domains can catalyze lysine d...
ORGANISM(S): Homo sapiens 
2010-04-26 | E-GEOD-20753 | biostudies-arrayexpress
TranscriptomicsPHF8 mediates histone demethylation events in cell cycle progression
This SuperSeries is composed of the following subset Series: GSE22477: PHF8 mediates histone demethylation events in cell cycle progression [expression] GSE22478: PHF8 mediates histone demethylation events in cell cycle progression [ChIP-Seq] Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-08-31 | E-GEOD-22400 | biostudies-arrayexpress
GenomicsRNA-seq data of PHF8 wild-type and PHF8 knockout TRAMP mouse
RNA-seq data of PHF8 wild-type and PHF8 knockout TRAMP mouse
PRJNA662246 | ENA
GenomicsAPOC2 increase PHF8 binding on chromatin
APOC2 increase PHF8 binding on chromatin
PRJNA464287 | ENA
ProteomicsPHF8 Demethylates YY1 to Regulate ETC Gene and mROS to Promote Cancer Cell Growth
High levels of mitochondrial reactive oxygen species (mROS) are linked to cancer development, which is tightly controlled by electron transport chain (ETC). Targeting ETC represents a promising way of curing cancers. However, the epigenetic mechanisms governing ETC gene transcription to drive mROS p...
ORGANISM(S): Homo Sapiens 
2022-06-07 | PXD034400 |
TranscriptomicsPHF8 mediates histone demethylation events in cell cycle progression [expression]
While reversible histone modifications are linked to an ever-expanding range of biological functions, the demethylases for histone H4 lysine 20 and their potential regulatory roles remain unknown. Here, we report that the PHD and Jumonji C (JmjC) domain-containing protein, PHF8, while utilizing mul...
ORGANISM(S): Homo sapiens 
2010-09-01 | E-GEOD-22477 | biostudies-arrayexpress
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