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MetabolomicsAnalysis of the human adult urinary metabolome variations with age, body mass index and gender by implementing a comprehensive workflow for univariate and OPLS statistical analyses. ('Sacurine' data set)

Urine metabolomics is widely used for biomarker research in the fields of medicine and toxicology. As a consequence, characterization of the variations of the urine metabolome under basal conditions becomes critical in order to avoid confounding effects in cohort studies. Such physiological infor...

2017-01-20 | MTBLS404 | MetaboLights
TranscriptomicsTranscription profiling of human tumours at baseline and after 21 days of treatment with sorafenib and dacarbazine
Background New approaches are needed to improve prognostic accuracy for treatment response and to explore the complexities of drug effects on human tumours. We developed a strategy of global genomic investigation of sequential tumor biopsies at baseline and 21 days post-treatment, and applied this ...
ORGANISM(S): Homo sapiens 
2010-07-31 | E-TABM-760 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lung large cell carncinoma cells grown under hypoxic conditions and treated with STAT3 siRNA
Hypoxia-mediated inhibition of specific tumour cell lysis
ORGANISM(S): Homo sapiens 
2009-03-12 | E-TABM-611 | biostudies-arrayexpress
GenomicsEGAS00001002091 - samples
Using sequencing and gene expression analyses, we identified a subgroup of HCA characterized by fusion of the INHBE and GLI1 genes and activation of sonic hedgehog pathway. Molecular subtypes of HCAs associated with different patients’ risk factors for HCA, disease progression, and pathology feature...
EGAD00001003092 | EGA
TranscriptomicsComparative genomic profile of human brain microvascular endothelial cells upon TWEAK or TNFα stimulation at 3h, 12h, and 24h
The molecular mechanisms playing a role in TWEAK versus TNFɑ signaling on cerebral microvascular endothelial cells are not well defined. Therefore, we aimed to identify gene expression changes in cultures of human brain microvascular endothelial cells (hCMEC/D3) to address changes initiated by TWEAK...
ORGANISM(S): Homo sapiens 
2022-10-20 | E-MTAB-12222 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in normal and Otx2-/- early gastrulating mouse embryos
We compared gene expression profiles in wild-type and Otx2(-/-) 6.5 days postcoitum embryos by using a serial analysis of gene expression assay adapted to microdissected structures. Among a broader list, the study of six genes found to be differentially expressed allows defining a role for Otx2 in t...
ORGANISM(S): Mus musculus 
2003-09-25 | E-GEOD-683 | biostudies-arrayexpress
ProteomicsTEAD inhibitor K-975 enhances KRASG12C inhibitor adagrasib-mediated cancer cell proliferation inhibition via dual cell cycle arrest
Here we investigate the effect of the dual inhibition, in KRASG12C mutated NSCLC cells, using the KRASG12Ci adagrasib (MRTX849) and the pan-TEAD inhibitor (TEADi) K-975. We show that K-975 enhances adagrasib-induced tumor cell growth inhibition in cancer cells. Mechanistically, we detect a downregul...
ORGANISM(S): Homo Sapiens (human) 
2023-05-12 | PXD039726 | JPOST Repository
TranscriptomicsArabidopsis thaliana Growth is Negatively Regulated by the Class III Peroxidase AtPrx71 during Development and in Response to Cell Wall Damage
The cell wall is a crucial structure in plant cells, and modifications in its composition often have a major impact on growth and development. However, the molecular mechanisms responsible for the negative effects of cell wall alterations on plant growth are largely unknown. It was previously shown ...
ORGANISM(S): Arabidopsis thaliana 
2016-01-06 | E-GEOD-66980 | biostudies-arrayexpress
TranscriptomicsOyster reproduction is affected by exposure to polystyrene microplastics
Plastics are persistent synthetic polymers that accumulate in the marine environment as waste. Microplastic (MP) particles are derived from the breakdown of larger debris or can enter the environment as microscopic fragments. Filter-feeder organisms ingest MP while feeding and are likely to be impac...
ORGANISM(S): Crassostrea gigas 
2016-01-15 | E-GEOD-71845 | biostudies-arrayexpress
TranscriptomicsCerebral malaria versus asymptomatic malaria
We hypothesized that differential gene expression contributes to phenotypic variation of parasites which results in specific interaction of Plasmodium falciparum with its human host. In this study we used microarray hybridization to analyse the transcriptomes of P.falciparum isolated from asymptoma...
ORGANISM(S): Plasmodium falciparum 
2014-12-01 | E-MTAB-2139 | biostudies-arrayexpress
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