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TranscriptomicsDepletion of Erk1 and Erk2 MAP kinases in primary human keratinocytes
We assessed the effect of RNAi-mediated MAP kinase cascade signaling blockade in primary human keratinocytes. Two sets of siRNA targeting different regions of the Erk1/2 genes were used, enabling identification of off-target siRNA effects. Primary human keratinocytes were electroporated with scra...
ORGANISM(S): Homo sapiens 
2009-05-03 | E-GEOD-15417 | biostudies-arrayexpress
ProteomicsDiagnosis and early detection of CNS-SLE in MRL/lpr mice using peptide microarrays (GPL14921)
We investigated whether mouse serum autoantibody binding patterns on random-sequence peptide microarrays (immunosignaturing) can be used for diagnosing and predicting the onset of lupus and its central nervous system (CNS) manifestations. Submitter states "We have no processed data to submit. ...
ORGANISM(S): Mus musculus 
2014-05-08 | E-GEOD-57388 | biostudies-arrayexpress
TranscriptomicsGamma radiation and HZE treatment of seedlings in Arabidopsis
Plants exhibit a robust transcriptional response to gamma radiation which includes the induction of transcripts required for homologous recombination and the suppression of transcripts that promote cell cycle progression. Various DNA damaging agents induce different spectra of DNA damage as well as ...
ORGANISM(S): Arabidopsis thaliana 
2014-09-18 | E-GEOD-61484 | biostudies-arrayexpress
UnknownQuantitative mapping of human hair greying and reversal in relation to life stress.
Not available
S-EPMC8219384 | biostudies-literature
TranscriptomicsAnalysis of genomic instability in esophageal squamous cell carcinoma (ESCC)
To characterize genomic instability in esophageal squamous cell carcinoma, we examined loss of heterozygosity, copy number loss, and copy number gain in ESCC patients from a high-risk region of China. Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted fr...
ORGANISM(S): Homo sapiens 
2010-04-10 | E-GEOD-15526 | biostudies-arrayexpress
ProteomicsGlomerular filtrate proteins in acute cardiorenal syndrome
Acute cardiorenal syndrome (CRS-1) is a morbid complication of acute cardiovascular disease. Mechanistic investigations have focused on intrarenal cellular signaling induced by ischemia/reperfusion. Additional cardiorenal connector signals have been postulated, but investigation in CRS-1 has been li...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-27 | PXD012193 | Pride
Cardiovascular disease Urine Isobaric labeling Mouse model Acute cardiorenal syndrome Quantitative proteomics Tandem mass tags 
UnknownEfficacy and Safety of Weekly Somatrogon vs Daily Somatropin in Children With Growth Hormone Deficiency: A Phase 3 Study.
Not available
S-EPMC9202717 | biostudies-literature
ProteomicsMicrobial alginate foraging is conserved in geographically and taxonomically distinct ruminant microbiomes
Saccharina latissima is a brown alga commonly found in the North Atlantic, Arctic and Pacific oceans. Alginate constitutes a substantial portion of the cell wall of S. latissima, and its digestion requires a specific set of enzymes, alginate lyases. We investigated if and how S. latissima is metabol...
ORGANISM(S): organismal metagenomes 
2026-04-16 | PXD059090 | Pride
TranscriptomicsExpression signatures of the lipid-based Akt inhibitors phosphatidylinositol ether lipid analogues in NSCLC cells
Activation of the serine/threonine kinase Akt contributes to the formation, maintenance, and therapeutic resistance of cancer, which is driving development of compounds that inhibit Akt. Phosphatidylinositol ether lipid analogues (PIAs) are analogues of the products of PI3K that inhibit Akt activat...
ORGANISM(S): Homo sapiens 
2011-03-22 | E-GEOD-27911 | biostudies-arrayexpress
TranscriptomicstRNAs marked with CCACCA are targeted for degradation
The CCA-adding enzyme adds CCA to the 3' ends of transfer RNAs (tRNAs), a critical step in tRNA biogenesis that generates the amino acid attachment site. We found that the CCA-adding enzyme plays a key role in tRNA quality control by selectively marking unstable tRNAs and tRNA-like small RNAs for de...
ORGANISM(S): Saccharomyces cerevisiae 
2011-11-17 | E-GEOD-33756 | biostudies-arrayexpress
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