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ProteomicsSilencing of the PHLDA1 leads to global proteome changes and differentiation pathways of human neuroblastoma cells
Neuroblastoma (NB) is the most common extracranial pediatric solid tumor originating from the abnormal development of cells of the sympathoadrenal lineage of the neural crest. Targeting GD2 ganglioside (GD2), a glycolipid expressed on neuroblastoma cells, with GD2 ganglioside-recognizing antibodies ...
ORGANISM(S): Homo sapiens (Human) 
2024-02-15 | PXD044319 | Pride
Human neuroblastoma cells Gd2 ganglioside-recognizing antibody Mass spectrometry Auts2 Phlda1 silencing 
ProteomicsPHLDA1 mediates drug resistance in receptor tyrosine kinase driven cancer
Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK) networks, and represents a critical challenge for precision medicine. Here we show that PHLDA1 down-regulation is critical to acquisition and maintenance of drug resistance in RTK-driven cancer. Using FGFR inh...
ORGANISM(S): Homo sapiens (Human) 
2018-03-05 | PXD008859 | Pride
Targeted therapy Tyrosine kinase inhibitor Akt Cancer Drug resistance Fgf 
GenomicsPHLDA1 is a shared diagnostic mediator for inflammatory fibrosis in heart and kidney
PHLDA1 is a shared diagnostic mediator for inflammatory fibrosis in heart and kidney
PRJNA1381625 | ENA
UnknownPHLDA1, another PHLDA family protein that inhibits Akt.
Not available
S-EPMC6215895 | biostudies-literature
UnknownPHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer.
Not available
S-EPMC5848852 | biostudies-literature
UnknownPHLDA1 Suppresses TLR4-Triggered Proinflammatory Cytokine Production by Interaction With Tollip.
Not available
S-EPMC8882599 | biostudies-literature
TranscriptomicsPHLDA1 is a shared diagnostic mediator for inflammatory fibrosis in heart and kidney
Background: Inflammation-driven fibrosis represents a common pathological endpoint in both heart failure (HF) and chronic kidney disease (CKD), which together affect over 1 billion people worldwide. Understanding the shared molecular mechanisms by which inflammation contributes to the pathogenesis o...
ORGANISM(S): Homo sapiens 
2026-02-25 | GSE313814 | GEO
GenomicsPHLDA1-PRDM1 mediates the effect of lentiviral vectors on fate-determination of human retinal progenitor cells
PHLDA1-PRDM1 mediates the effect of lentiviral vectors on fate-determination of human retinal progenitor cells
PRJNA1055163 | ENA
UnknownPHLDA1 Does Not Contribute Directly to Heat Shock-Induced Apoptosis of Spermatocytes.
Not available
S-EPMC6982182 | biostudies-literature
UnknownPHLDA1 expression in ulcerative colitis: A potential role in the management of dysplasia.
Not available
S-EPMC8327077 | biostudies-literature
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