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ProteomicsDifferential alkylation of PHLPP2
To determine the accessibility of cysteines in purified PHLPP2, we assessed their reactivity with iodoacetamide under native conditions. After denaturing with urea and reducing potential disulfide bridges with TCEP, the remaining free cysteines were modified with methyl methanethiosulfonate. This 2-...
ORGANISM(S): Homo sapiens (Human) 
2025-03-13 | PXD052551 | Pride
Differential alkylation Free thiols 
ProteomicsPeptide fingerprinting of purified recombinant human PHLPP2
Peptide fingerprinting to establish whether there is any contaminating phosphatase(s) in the purified protein.
ORGANISM(S): Spodoptera frugiperda Homo sapiens (Human) 
2025-03-13 | PXD045978 | Pride
Human phlpp2 
GenomicsPHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor
PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor
PRJNA1214704 | ENA
TranscriptomicsPHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor
The phosphoinositide 3-kinase (PI3K) pathway is a major regulator of cell and organismal growth. Consequently, hyperactivation of PI3K and its downstream effector kinase, Akt, is observed in many human cancers. PH domain leucine-rich repeat-containing protein phosphatases (PHLPP), two paralogous mem...
ORGANISM(S): Homo sapiens 
2025-04-02 | GSE287792 | GEO
UnknownAdipocyte PHLPP2 inhibition prevents obesity-induced fatty liver.
Not available
S-EPMC7988046 | biostudies-literature
UnknownDegradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis.
Not available
S-EPMC5705280 | biostudies-literature
UnknownPhosphatase PHLPP2 regulates the cellular response to metabolic stress through AMPK.
Not available
S-EPMC8490465 | biostudies-literature
UnknownThe PHLPP2 phosphatase is a druggable driver of prostate cancer progression.
Not available
S-EPMC6548123 | biostudies-literature
UnknownmTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2.
Not available
S-EPMC4729872 | biostudies-literature
UnknownTRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma.
Not available
S-EPMC10781680 | biostudies-literature
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