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MetabolomicsMass spectrometry imaging of phosphatidylcholine metabolism in lungs administered with therapeutic surfactants and isotopic tracers

Mass spectrometry imaging (MSI) visualises molecular distributions throughout tissues but is blind to dynamic metabolic processes. Here, MSI with high mass resolution together with multiple stable isotope labelling provided spatial analyses of phosphatidylcholine (PC) metabolism in mouse lungs. D...

2020-10-30 | MTBLS2075 | MetaboLights
MetabolomicsPhosphatidylcholine in wheat anthers is a susceptibility factor for Fusarium head blight
Fusarium head blight is a devastating wheat disease that initiates at flowering, with anthers as the preferred infection site. However, the anther-derived molecules driving this susceptibility remain elusive. Here, we identify anther-enriched phosphatidylcholine, particularly PC(18:2/18:2) and PC(16...
2026-06-23 | MTBLS14814 | MetaboLights
MetabolomicsPhosphatidylcholine in wheat anthers is a susceptibility factor for Fusarium head blight

Non-targeted metabolomics was performed to investigate the metabolic differences between fertile and sterile wheat anthers, and to identify anther-derived metabolites that promote Fusarium head blight infection. Wheat anthers (fertile, sterile, and fertile anthers co-cultured with Fusarium gramin...

2026-06-23 | MTBLS14831 | MetaboLights
TranscriptomicsGlobal consequences of phosphatidylcholine reduction in Bradyrhizobium japonicum
Analysis of a Bradyrhizobium japonicum pmtA mutant. PmtA catalyzes the first of three consecutive methylation reactions leading to phosphatidylcholine (PC) formation in B. japonicum. Disruption of the pmtA gene results in a significantly reduced PC content causing a defect in symbiosis with the soyb...
ORGANISM(S): Bradyrhizobium japonicum 
2008-04-17 | E-GEOD-11187 | biostudies-arrayexpress
MetabolomicsAnalysis of short chain phosphatidylcholine (PC) on the Golgi membrane
Not available
ORGANISM(S): Cricetulus griseus 
ST001177 | MetabolomicsWorkbench
TranscriptomicsActivation of phosphatidylcholine-cycle enzymes in human epithelial ovarian cancer cells
Altered phosphatidylcholine (PC) metabolism in epithelial ovarian cancer (EOC) can provide choline-based imaging approaches as powerful tools to improve diagnosis and identify new therapeutic targets. Biochemical, protein and mRNA expression analyses demonstrated that the increase in the major choli...
ORGANISM(S): Homo sapiens 
2009-12-07 | E-GEOD-19352 | biostudies-arrayexpress
TranscriptomicsRegulatory Role for PC-TP/StarD2 in the Metabolic Response to Peroxisome Proliferator Activated Receptor Alpha (PPARα)
Phosphatidylcholine transfer protein (PC-TP, a.k.a StarD2) is abundantly expressed in liver and is regulated by PPARα. When fed the synthetic PPARα ligand fenofibrate, Pctp-/- mice exhibited altered lipid and glucose homeostasis. Microarray profiling of liver from fenofibrate fed wild type and Pct...
ORGANISM(S): Mus musculus 
2010-08-12 | E-GEOD-17666 | biostudies-arrayexpress
TranscriptomicsTranscriptomic characterization of a virulence-deficient phosphatidylcholine-negative Agrobacterium tumefaciens mutant
To learn more about the global effects of phosphatidylcholine (PC)-deficiency in A. tumefaciens, we performed transcriptomic studies comparing the wild type and a PC-deficient DpmtA Dpcs mutant. We expanded the number of affected virulence genes and showed that the loss of PC was correlated with alt...
ORGANISM(S): Agrobacterium tumefaciens str. C58 
2010-04-07 | E-GEOD-21223 | biostudies-arrayexpress
MetabolomicsHepatic Phosphatidylcholine Catabolism Driven by PNPLA7 and PNPLA8 Supplies Endogenous Choline to Replenish the Methionine Cycle with Methyl Groups (Pnpla7-knockout)
Not available
ORGANISM(S): Mus musculus 
ST002377 | MetabolomicsWorkbench
MetabolomicsHepatic Phosphatidylcholine Catabolism Driven by PNPLA7 and PNPLA8 Supplies Endogenous Choline to Replenish the Methionine Cycle with Methyl Groups(Pnpla8-knockout)
Not available
ORGANISM(S): Mus musculus 
ST002376 | MetabolomicsWorkbench
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