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MetabolomicsDeficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2...
2018-01-25 | MTBLS600 | MetaboLights
GenomicsTargeting phosphatidylserine for tumor cell suppression [RNA-seq]
Targeting phosphatidylserine for tumor cell suppression [RNA-seq]
PRJNA1458133 | ENA
GenomicsTafazzin Regulates Cell State by Modulating Phosphatidylethanolamine and Phosphatidylserine levels
Tafazzin Regulates Cell State by Modulating Phosphatidylethanolamine and Phosphatidylserine levels
PRJNA418909 | ENA
GenomicsSoybean derived phosphatidylserine synthetically targets OTUB2 epigenetic silencing in squamous cell carcinoma
Soybean derived phosphatidylserine synthetically targets OTUB2 epigenetic silencing in squamous cell carcinoma
PRJNA721679 | ENA
GenomicsSuppressing phosphatidylserine externalization overcomes cancer immune evasion and enhances immunotherapy
Suppressing phosphatidylserine externalization overcomes cancer immune evasion and enhances immunotherapy
PRJNA1508749 | ENA
TranscriptomicsTafazzin Regulates Cell State by Modulating Phosphatidylethanolamine and Phosphatidylserine levels
Inhibiting tafazzin a cardiolipin remodeling enzyme reduces stemness of AML by modulating the level of phosphatidylserine
ORGANISM(S): Homo sapiens 
2019-03-28 | GSE107045 | GEO
TranscriptomicsTargeting phosphatidylserine for tumor cell suppression [RNA-seq]
Alterations in lipid metabolism are frequently observed in cancers, playing a pivotal role in tumor cell survival and proliferation. Phosphatidylserine (PS), the most negatively charged glycerophospholipid in eukaryotic membranes, is synthesized in mammals by key enzymes, such as phosphatidylserine ...
ORGANISM(S): Homo sapiens 
2026-08-05 | GSE329207 | GEO
TranscriptomicsPtdsr-/- (phosphatidylserine receptor) fibroblasts
Phagocytosis of apoptotic cells is fundamental to animal development, immune function and cellular homeostasis. The phosphatidylserine receptor (Ptdsr) on phagocytes has been implicated in the recognition and engulfment of apoptotic cells and in anti-inflammatory signaling. Ptdsr is essential for th...
ORGANISM(S): Mus musculus 
2007-03-01 | GSE6937 | GEO
TranscriptomicsPtdsr (phosphatidylserine receptor) embryos
Phagocytosis of apoptotic cells is fundamental to animal development, immune function and cellular homeostasis. The phosphatidylserine receptor (Ptdsr) on phagocytes has been implicated in the recognition and engulfment of apoptotic cells and in anti-inflammatory signaling. Ptdsr is essential for th...
ORGANISM(S): Mus musculus 
2007-03-01 | GSE6938 | GEO
GenomicsContext-dependent compensation among phosphatidylserine-recognition receptors
Context-dependent compensation among phosphatidylserine-recognition receptors
PRJNA416250 | ENA
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