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TranscriptomicsTranscription profiling of human mesenchymal stem cell-derived osteoblasts following RNAi knock down of phosphodiesterase 7 and 8A
Effects of phosphodiesterase 7 and 8A inhibition by RNA Interference on the gene expression of human mesenchymal stem cell-derived osteoblasts.
ORGANISM(S): Homo sapiens 
2008-12-12 | E-MEXP-1021 | biostudies-arrayexpress
ProteomicsNucleotide pyrophosphatase/phosphodiesterase from Euphorbia characias latex
The low-resolution structure of a nucleotide pyrophosphatase/phosphodiesterase from Euphorbia characias latex (ELNPP) has been determined in solution by means of Small Angle X-ray Scattering (SAXS). To improve the structural resolution of ELNPP a partial sequencing after proteolytic cleavage of the ...
ORGANISM(S): Euphorbia characias 
2022-03-02 | PXD009976 | Pride
Nucleotide pyrophosphatase/phosphodiesterase Euphorbia characias Msms sequencing 
TranscriptomicsThe YmdB phosphodiesterase is a global regulator of biofilm-specific mRNA levels in Bacillus subtilis
Detailed description (other than provided below) of growth conditions, RNA preparation, cDNA synthesis and hybridization conditions can be found in the submitted paper. GSM956794-GSM956801: Bacillus subtilis 168 wild type and its ymdB derivative strain were grown in CSE-Glu medium and cells were ha...
ORGANISM(S): Bacillus subtilis 
2013-12-11 | E-GEOD-39142 | biostudies-arrayexpress
TranscriptomicsMicroarray profiling of WT or PDE10A KO mice treated with vehicle or a PDE10 inhibitor
Inhibition of phosphodiesterase 10A (PDE10A) promotes cyclic nucleotide signaling, increases striatal activation, and decreases behavioral activity. Enhanced cyclic nucleotide signaling is a well established route to producing changes in gene expression. We hypothesized that chronic suppression of P...
ORGANISM(S): Mus musculus 
2012-08-25 | E-GEOD-40377 | biostudies-arrayexpress
ProteomicsMutagenesis of Key Phosphodiesterases in Toxoplasma gondii Demonstrates the Plasticity and Therapeutic Potential of Cyclic Nucleotide Signaling
Cyclic nucleotide signaling is pivotal to the asexual growth of T. gondii; however, little do we know about its counter-regulation in this parasite. We identified 18 phosphodiesterase (PDE1-18) enzymes, most of which form apicomplexan-specific clades and lack typical regulatory motifs found in mamma...
ORGANISM(S): Cellular Organisms 
2023-02-22 | PXD032173 | JPOST Repository
TranscriptomicsInhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination
We used transcription-profiling to identify mitogen-activated protein kinase (Mapk) signaling as an important regulator involved in the differentiation of oligodendrocyte progenitor cells (OPCs) into oligodendrocytes. We show in tissue culture that activation of Mapk signaling by elevation of intrac...
ORGANISM(S): Rattus norvegicus 
2013-08-29 | E-GEOD-50042 | biostudies-arrayexpress
TranscriptomicsMutant p53 cooperates with ETS2 to promote etoposide resistance [ChIP-chip]
Mutant p53 (mtp53) promotes chemotherapy resistance through multiple mechanisms including disabling pro-apoptotic proteins and by regulating gene expression. Analysis of promoter regions identified through CHIP-on-CHIP and CHIP-SEQ platforms reveal that the ETS motif (EBS) is prevalent within predic...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-36751 | biostudies-arrayexpress
GenomicsMutant p53 cooperates with ETS2 to promote etoposide resistance [ChIP-Seq]
Mutant p53 (mtp53) promotes chemotherapy resistance through multiple mechanisms including disabling pro-apoptotic proteins and by regulating gene expression. Analysis of promoter regions identified through CHIP-on-CHIP and CHIP-SEQ platforms reveal that the ETS motif (EBS) is prevalent within predic...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-36749 | biostudies-arrayexpress
UnknownDetergents stabilize the conformation of phosphodiesterase 6.
Not available
S-EPMC3215081 | biostudies-literature
UnknownMutations in phosphodiesterase 6 identified in familial cases of retinitis pigmentosa.
Not available
S-EPMC5112436 | biostudies-literature
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