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ProteomicsPKM2 functions as a histidine kinase to phosphorylate PGAM1 to increase glycolysis shunts in cancer
Phosphoglycerate mutase 1 (PGAM1) is a key-node enzyme that diverts the metabolic intermediates from glycolysis into its shunts to support macromolecule biosynthesis for rapid and sustainable cell proliferation. It is prevalent that PGAM1 activity is upregulated in various tumors; however, the under...
ORGANISM(S): Homo sapiens (Human) 
2024-03-21 | PXD049235 | Pride
Glycolysis shunts Pyruvate kinase m2 (pkm2) Histidine kinase Phosphorylation Phosphoglycerate mutase 1 (pgam1) 
ProteomicsPKM2 functions as a histidine kinase to phosphorylate PGAM1 to increase glycolysis shunts in cancer-Cellular lipid level assessment
Phosphoglycerate mutase 1 (PGAM1) is a key node enzyme that diverts the metabolic reactions from glycolysis into its shunts to support macromolecule biosynthesis for rapid and sustainable cell proliferation. It is prevalent that PGAM1 activity is upregulated in various tumors; however, the underlyin...
ORGANISM(S): Homo sapiens (Human) 
2024-03-21 | PXD049310 | Pride
Glycolysis shunts Pyruvate kinase m2 (pkm2) Histidine kinase Phosphorylation Phosphoglycerate mutase 1 (pgam1) 
UnknownBisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate.
Not available
S-EPMC5605442 | biostudies-literature
UnknownPhosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.
Not available
S-EPMC3500524 | biostudies-literature
UnknownIdentification of Epigallocatechin-3- Gallate as an Inhibitor of Phosphoglycerate Mutase 1.
Not available
S-EPMC5447756 | biostudies-literature
UnknownDiffering impact of phosphoglycerate mutase 1-deficiency on brown and white adipose tissue.
Not available
S-EPMC9065309 | biostudies-literature
UnknownSaturated fatty acid- and/or monounsaturated fatty acid-containing-phosphatidic acids selectively interact with and activate phosphoglycerate mutase 1.
Not available
S-EPMC12513065 | biostudies-literature
UnknownDevelopment of Anthraquinone Analogues as Phosphoglycerate Mutase 1 Inhibitors.
Not available
S-EPMC6429356 | biostudies-literature
MetabolomicsMetabolite profiling of Arabidopsis mutants of enzymes of lower glycolysis
We have previously shown that in Arabidopsis the three enzymes of lower glycolysis phosphoglycerate mutase (PGAM), enolase and pyruvate kinase form a complex which play an important role in co-sub-cellar localization the mitochondria to the chloroplast. Given that their metabolites of these mutants,...
2022-10-10 | MTBLS4066 | MetaboLights
UnknownRegulation of glycolytic enzyme phosphoglycerate mutase-1 by Sirt1 protein-mediated deacetylation.
Not available
S-EPMC3281715 | biostudies-literature
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