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TranscriptomicsResistance to PI3K/mTOR inhibitor PF-04691502 in KRAS mutant colorectal cancer models reveals a sensitivity to combination with EGFR inhibition
We explored potential bypass mechanisms to PI3K/mTOR-directed therapy in KRAS mutant CRC models, utilizing genetically engineered mouse models (GEMM) to generate acquired resistance to the targeted dual PI3K/mTOR small molecule inhibitor PF-04691502. Transcriptomic analysis revealed a dynamic stem-l...
ORGANISM(S): Mus musculus 
2014-08-31 | E-MTAB-2510 | biostudies-arrayexpress
TranscriptomicsComparative study of a mTOR inhibitor, a pan-PI3K inhibitor and a dual PI3K/mTOR inhibitor in MCL
Phosphatidylinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway activation contributes to mantle cell lymphoma (MCL) pathogenesis and drug resistance. However, the use of mTOR inhibitors as single agents have shown limited clinical efficacy in relation with drug activation of f...
ORGANISM(S): Homo sapiens 
2013-12-14 | E-GEOD-53309 | biostudies-arrayexpress
GenomicsSUM52PE treated with PI3K-mTOR inhibitors
SUM52PE treated with PI3K-mTOR inhibitors
PRJNA509669 | ENA
TranscriptomicsCombined PI3K/mTOR and MEK Inhibition Provides Broad Anti-Tumor Activity in Faithful Murine Cancer Models
Anticancer drug development is an inefficient process, with potential therapeutics demonstrating a high attrition rate due to lack of efficacy in Phase II/III testing. In an effort to develop improved pre-clinical predictors of efficacy, we and others have turned to testing in genetically engineere...
ORGANISM(S): Mus musculus 
2012-08-21 | E-GEOD-35722 | biostudies-arrayexpress
TranscriptomicsCopy number profiling of 92 human lung tumors on Affymetrix 100K SNP arrays
Copy number profiling of 92 human lung tumors on Affymetrix 100K SNP arrays was conducted in order to assess the interaction of common genomic alterations with response to targeted anti-cancer therapeutics. Class 1 phosphatidylinositol 3' kinase (PI3K) plays a major role in cell proliferation and su...
ORGANISM(S): Homo sapiens 
2013-01-10 | E-GEOD-39793 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of colon cancer cell SW480_Control, _BOP1, _CKS2 and _NFIL3 treated with different inhibitors
SW480 cells overexpressing BOP1, CKS2 or NFIL3 migrated more actively compared to Control cells. Migration induced by BOP1, CKS2 or NFIL3 was repressed by interfering with distinct signaling systems using small- molecular-weight inhibitors, i.e., interference with PI3K, JNK and Notch in the case of ...
ORGANISM(S): Homo sapiens 
2015-08-04 | E-GEOD-50841 | biostudies-arrayexpress
TranscriptomicsSynergistic anti-tumor activity by association of MEK and PI3K/mTOR blockade with TRAIL in human melanoma
Combining direct anti-tumor effects with targeting of tumor microenvironment is an attractive strategy that may lead to more effective therapies for advanced melanoma. Here, we tested whether association of TRAIL with co-targeting of MEK and PI3K/mTOR, or with MEK blockade, could have synergistic a...
ORGANISM(S): Homo sapiens 
2014-10-08 | E-GEOD-55050 | biostudies-arrayexpress
ProteomicsRNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition
Fang L, Ford-Roshon D, Russo M, O'Brien C, Xiong X, Gurjao C, Grandclaudon M, Raghavan S, Corsello SM, Carr SA, Udeshi ND, Berstler J, Sicinska E, Ng K, Giannakis M. 2022. The RNF43_p.G659fs mutation occurs frequently in colorectal cancer, but its function remains poorly understood and there are no ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-04-29 | MSV000089343 | MassIVE
ProteomicsPI3K/mTOR specific phospho-antibody microarray to study the effect of rapamycin to the innate immune respsonse
To comprehensively analyze the effects of mTORC1 inhibition on GSK3, we employed the use of a PI3K/mTOR-specific phospho-antibody microarray that analyzed the site-specific phosphorylation of over 130 kinases within the PI3K/mTOR pathway. The phosphorylation levels of different kinases in monocytes...
ORGANISM(S): Homo sapiens 
2010-11-25 | E-GEOD-25520 | biostudies-arrayexpress
TranscriptomicsTargeting the Phosphoinositide 3-Kinase p110-alpha Isoform Impairs Cell Proliferation, Survival and Tumor Growth in Small Cell Lung Cancer
Purpose: The phosphoinositide 3-kinase (PI3K) pathway is fundamental for cell proliferation and survival and is frequently altered and activated in neoplasia, including carcinomas of the lung. In this study we investigated the potential of targeting the catalytic class IA PI3K isoforms in small cell...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-40564 | biostudies-arrayexpress
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