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TranscriptomicsTranscription profiling of mouse HA specific T regulatory cells cultured in the presence of HA-pulsed dendritic cells and rhIL-2 with or without HA-specific T effector cells
Expanded HA-specific Thy-1.1 Tregs were cultured in the presence of HA-pulsed dendritic cells and rhIL-2 with or without HA-specific Teffs. After 5 days, Tregs were sorted by flow cytometry, based on the expression of the Thy-1.1 congeneic marker. Two biological duplicates were hybridized to the Sen...
ORGANISM(S): Mus musculus 
2009-09-08 | E-MTAB-146 | biostudies-arrayexpress
TranscriptomicsHeterogeneous CD3 expression levels in differing T-cell subsets account for in vivo anti-CD3-mediated immune resetting
The tolerogenic anti-CD3 monoclonal antibodies (anti-CD3) are promising compounds for the treatment of type 1 diabetes (T1D). Anti-CD3 administration induces transient T-cell depletion both in preclinical and in clinical studies. Notably, said depletion mainly affects CD4+ but not CD8+ T cells. More...
ORGANISM(S): FoxP3-GFP NOD mouse 
2015-01-19 | E-MTAB-2437 | biostudies-arrayexpress
TranscriptomicsRole of IL-17RA in the development of parasite-specific cytotoxic responses during Trypanosoma cruzi infection
IL-17RA knockout mice presented increased tissue parasitism during T. cruzi infection that correlated with a reduced frequency of parasite-specific CD8+ T cells. Parasite-specific CD8+ T cells from KO mice showed similar proliferation rate but increased mortality and an exhausted phenotype when comp...
ORGANISM(S): Mus musculus 
2020-01-31 | E-MTAB-2438 | biostudies-arrayexpress
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