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TranscriptomicsPivotal role of HMGA1 gene signature in highly metastatic breast cancer
Analysis of MDA-MB-231 breast cancer cells depleted for High Mobility Group A1 (HMGA1) using siRNA. HMGA1 is involved in invasion and metastasis in breast cancer cells. Results identify the specific transcriptional program induced by HMGA1 in highly metastatic breast cancer cells. MDA-MB-231 cells w...
ORGANISM(S): Homo sapiens 
2013-12-10 | E-GEOD-35525 | biostudies-arrayexpress
TranscriptomicsImpact of mutant p53 on TNF-induced gene expression
MDA-MB-231 are a metastatic triple-negative breast cancer cell line that bears a missense p53 mutation (R280K). We depleted endogenous mutp53 in MDA-MB-231 cells by siRNA transfection, and treated the cells with Tumor Necrosis Factor (TNF)-alpha. Microarray analysis was performed to evaluate the imp...
ORGANISM(S): Homo sapiens 
2014-10-27 | E-GEOD-53153 | biostudies-arrayexpress
TranscriptomicsPin1/mutant-p53 jointly controlled genes
To investigate the specific gene expression program by which mutant-p53 and Pin1 control invasion and metastasis in breast cancer cells, we compared the transcriptomic profile of control, mutant-p53 depleted or Pin1 depleted MDA-MB-231 cells. MDA-MB-231 cells were transfected twice with siRNA agains...
ORGANISM(S): Homo sapiens 
2011-05-30 | E-GEOD-26262 | biostudies-arrayexpress
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