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TranscriptomicsComplete TLR3 deficiency
The objective of this study is to study the Toll-like receptor 3 (TLR3)-dependent gene expression in human fibroblast cells and peripheral blood mononuclear cells (PBMCs) Fibroblast cells and PBMCs from donors with autosomal recessive (AR) complete TLR3 deficiency and autosomal dominant (AD) partial...
ORGANISM(S): Homo sapiens 
2011-11-02 | E-GEOD-30951 | biostudies-arrayexpress
TranscriptomicsDelta lgt paper
We have used a lipoprotein-deficient mutant Streptococcus pneumoniae strain, delta lgt, to investigate the role of lipoproteins during inflammatory responses to live S. pneumoniae.
ORGANISM(S): Homo sapiens 
2015-01-31 | E-MTAB-1541 | biostudies-arrayexpress
TranscriptomicsResponse of IRF7-deficient peripheral blood mononuclear cells to pH1N1 influenza virus infection
IRF7 plays a critical role in the production and amplification of the antiviral type I and III interferon response. Autosomal recessive IRF7-deficiency resulted in life-threatening influenza disease in a 3-year-old child. We studied the impact of IRF7-deficiency in non-hematopoietic tissues (fibrobl...
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-66486 | biostudies-arrayexpress
TranscriptomicsIn vitro responses of PBMC and fibroblasts from patients with TRIF deficiency after TRIF dependent and independent stimuli
We report here unrelated HSE patients with autosomal recessive (AR) or autosomal dominant (AD) TRIF deficiency. The AR form of the disease is due to a homozygous nonsense mutation, resulting in a complete absence of the TRIF protein. Both the TLR3 and the TRIF-dependent TLR4 signaling pathways are a...
ORGANISM(S): Homo sapiens 
2011-10-19 | E-GEOD-32390 | biostudies-arrayexpress
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