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GenomicsA Novel HDAC Complex in the Control of Transcription and Genome Stability
The acetylation state of histones, controlled by histone acetyltransferases and deacetylases, profoundly affects DNA transcription and repair by modulating chromatin accessibility to the cellular machinery. The Schizosaccharomyces pombe HDAC Clr6 (human HDAC1) binds to different sets of proteins tha...
ORGANISM(S): Schizosaccharomyces pombe 
2014-07-10 | E-GEOD-57040 | biostudies-arrayexpress
GenomicsChromosome 11 analysis in myeloid malignancies - WES
Blood samples from patients with myeloid malignancies were analyzed using whole exome sequencing (WES). Data set from genotyping by microarray of the same samples has been deposited in ArrayExpress under accession number E-MTAB-1845 (https://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-1845/).
ORGANISM(S): Homo sapiens 
2013-11-01 | E-MTAB-1850 | biostudies-arrayexpress
GenomicsAuthentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1
Whole genome sequencing (WGS) from snap-frozen oesophageal tumour tissue and germline nucleic acids isolated from peripheral blood mononuclear cells (PBMC) was performed as part of the International Cancer Genome Consortium project and OCCAMS consortium (1,2). Filtered read sequences were mapped to ...
ORGANISM(S): Homo sapiens 
2016-09-09 | E-MTAB-4600 | biostudies-arrayexpress
GenomicsWhole Genome Sequencing of MCF10A cells
The non-tumourigenic human breast epithelial cell line MCF10A is the cell line most commonly used as a model for normal human breast cells. This dataset provides a reference genome for MCF10A. The whole genome, high-throughput sequencing was performed using the Illumina NovaSeq 6000 PE150 system. Bo...
ORGANISM(S): Homo sapiens 
2023-10-01 | E-MTAB-13191 | biostudies-arrayexpress
TranscriptomicsThe acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosis
It is well known that both recipient cells and donor nuclei demonstrate a mitotic advantage as observed in the traditional reprogramming with somatic cell nuclear transfer (SCNT). However, It is not known whether a specific mitotic factor plays a critical role in reprogramming. Here we identify an i...
ORGANISM(S): Homo sapiens 
2016-03-01 | E-GEOD-66798 | biostudies-arrayexpress
UnknownMarkers of systemic inflammation are positively associated with influenza vaccine antibody responses with a possible role for ILT2(+)CD57(+) NK-cells.
Not available
S-EPMC9134679 | biostudies-literature
ProteomicsDYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer
Highly malignant pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundant immunosuppressive and fibrotic tumor microenvironment (TME). Future therapeutic attempts therefore demand targeting of both compartments in order to be effective. We show here that Dual Specificity and Tyrosine...
ORGANISM(S): Mus Musculus 
2024-01-02 | MSV000093747 | MassIVE
TranscriptomicsComplete hematologic response of early-T-cell progenitor acute lymphoblastic leukemia to the gamma-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case
Notch pathway antagonists such as gamma-secretase inhibitors (GSI) are being tested in diverse cancers, but exceptional responses have yet to be reported. We describe the case of a patient with relapsed/refractory early-T-cell progenitor acute lymphoblastic leukemia (ETP-ALL) who achieved a complete...
ORGANISM(S): Homo sapiens 
2015-07-29 | E-GEOD-71414 | biostudies-arrayexpress
GenomicsIdentification of maternal imprinting control regions (ICRs) in the post-implantation mouse embryo.
Genomewide DNA methylation profiles, generated by MeDIP-seq, for 8.5dpc wildtype and Dnmt3l-/+ mouse embryos were compared to identify differentially methylated regions (DMRs) that depend on the activity of the de novo DNA methyltransferase cofactor Dnmt3l in the oocyte. These DMRs were further char...
ORGANISM(S): Mus musculus 
2012-10-04 | E-GEOD-32687 | biostudies-arrayexpress
TranscriptomicsThe Transcriptional Stress Response of Candida albicans to Weak Organic Acids
Candida albicans is the most important fungal pathogen of humans, causing severe infections especially in nosocomial and immunocompromised settings. However, it is also the most prevalent fungus of the normal human microbiome, where it shares its habitat with hundreds of trillions of other microbia...
ORGANISM(S): Candida albicans 
2015-01-28 | E-GEOD-49310 | biostudies-arrayexpress
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