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ProteomicsA single T cell epitope drives the neutralizing anti-drug antibody response to natalizumab in multiple sclerosis patients
Natalizumab (NZM), a humanized monoclonal IgG4 antibody to α4 integrins, is used to treat patients with relapsing-remitting multiple sclerosis (MS), but in about 6% of the cases persistent neutralizing anti-drug antibodies (ADAs) are induced leading to therapy discontinuation. To understand the basi...
ORGANISM(S): Homo sapiens (Human) 
2019-10-10 | PXD013599 | Pride
Antibody therapy Mhc-ii peptidomics Multiple sclerosis Human 
ProteomicsA single T cell epitope drives the neutralizing anti-drug antibody response to natalizumab in multiple sclerosis patients
Natalizumab (NZM), a humanized monoclonal IgG4 antibody to ?4 integrins, is used to treat patients with relapsing-remitting multiple sclerosis (MS), but in about 6% of the cases persistent neutralizing anti-drug antibodies (ADAs) are induced leading to therapy discontinuation. To understand the basi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-06-27 | MSV000098354 | MassIVE
TranscriptomicsEffect of deferasirox and deferoxamine treatment on hematopoietic stem cells gene expression
To investigate new molecular pathways affected by deferasirox or deferoxamine able to explain hematopoiesis restoration
ORGANISM(S): Homo sapiens 
2019-09-02 | E-MTAB-6658 | biostudies-arrayexpress
UnknownDeferasirox drives ROS-mediated differentiation and induces interferon-stimulated gene expression in human healthy haematopoietic stem/progenitor cells and in leukemia cells.
Not available
S-EPMC6567456 | biostudies-literature
UnknownUnderstanding barriers and optimizing socio-cognitive assessment in the diagnosis of neurocognitive disorders.
Not available
S-EPMC12424105 | biostudies-literature
UnknownThe Impact of COVID-19 Quarantine on Patients With Dementia and Family Caregivers: A Nation-Wide Survey.
Not available
S-EPMC7849158 | biostudies-literature
UnknownAccuracy of the clinical diagnosis of dementia with Lewy bodies (DLB) among the Italian Dementia Centers: a study by the Italian DLB study group (DLB-SINdem).
Not available
S-EPMC9213280 | biostudies-literature
UnknownCommunication and visiting policies in Italian intensive care units during the first COVID-19 pandemic wave and lockdown: a nationwide survey.
Not available
S-EPMC9203262 | biostudies-literature
UnknownRisk factors for anastomotic leakage after anterior resection for rectal cancer (RALAR study): A nationwide retrospective study of the Italian Society of Surgical Oncology Colorectal Cancer Network Collaborative Group.
Not available
S-EPMC9300066 | biostudies-literature
UnknownThe Emergency Surgery Frailty Index (EmSFI): development and internal validation of a novel simple bedside risk score for elderly patients undergoing emergency surgery.
Not available
S-EPMC8302529 | biostudies-literature
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