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ProteomicsComparison of denatured and non-denatured FIH interactomes
Hypoxia occurs when tissue or cellular oxygen demand exceeds its supply and is a frequent condition in health and disease. Metazoans have developed a regulatory system that allows them to sense changes in oxygen levels in their microenvironment and adapt to them. The asparagine hydroxylase factor in...
ORGANISM(S): Homo sapiens (Human) 
2019-07-09 | PXD011252 | Pride
Covalent bond Oxygen Hypoxia Amide bond Asparagine hydroxylase Hif 
ProteomicsFIH regulates cellular metabolism through hydroxylation of the deubiquitinase OTUB1.
The asparagine hydroxylase, factor inhibiting HIF (FIH) confers oxygen-dependence upon the hypoxia-inducible factor (HIF), a master regulator of the cellular adaptive response to hypoxia. Studies investigating whether asparagine hydroxylation is a general regulatory oxygen-dependent modification hav...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080695 | MassIVE
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