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TranscriptomicsGene expression profiling of novel antigen presenting cells (APC) inducing pathogenic T helper cells of lupus
In lupus autoimmunity, pathogenic IgG autoantibodies that fix complement and bind FcGammaR on inflammatory cells, are produced with help from T helper (Th1 and Th17) cells specific for peptides from nucleosomes of apoptotic cells; and these Th cells also infiltrate vital organs (1-9). Macrophages (...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-36284 | biostudies-arrayexpress
ProteomicsTranslational and post-translational dynamics in a model peptidergic system
The cell bodies of hypothalamic magnocellular neurones are densely packed in the hypothalamic supraoptic nucleus whereas their axons project to the anatomically discrete posterior pituitary gland. We have taken advantage of this unique anatomical structure to establish proteome and phosphoproteome d...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-04-12 | PXD040870 | Pride
Cytoskeleton Phosphoproteome Posterior pituitary Supraoptic nucleus Proteome 
ProteomicsLow-protein/high carbohydrate diet
Low-protein/high carbohydrate (LP/HC) diet promotes metabolic health and longevity in adult human and animal models. However, the complex molecular underpinnings of how LP/HC diet leads to metabolic benefits remain elusive. Through a multi-layered approach, here we observed that LP/HC diet promotes ...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD017786 | Pride
Adipose tissue Diet 
ProteomicsVDAC2 ligands selectively and potently block BAK-mediated apoptosis to allow long-term clonogenic cell survival
This study aimed to characterise the protein that a novel compound binds to, thus promoting its ability to inhibit BAK apoptotic activity.
ORGANISM(S): Homo sapiens (Human) 
2019-10-11 | PXD013129 | Pride
Compound target id 
UnknownDeterminants of survival and major amputation after peripheral endovascular intervention for critical limb ischemia.
Not available
S-EPMC5315445 | biostudies-literature
UnknownA comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV.
Not available
S-EPMC12227296 | biostudies-literature
TranscriptomicsLim Homeobox Gene, LHX8, Is Essential for Mouse Oocyte Differentiation and Survival
Lhx8 is a member of the LIM-homeobox transcription factor family and preferentially expressed in oocytes and germ cells within the mouse ovary. We discovered that Lhx8 knockout females lose oocytes within 7 days after birth. At the time of birth, histological examination shows that Lhx8 deficient (L...
ORGANISM(S): Mus musculus 
2008-06-25 | E-GEOD-11897 | biostudies-arrayexpress
TranscriptomicsHSF4 deficient lens of newborn mice
Microarray Analyses of Newborn Mouse lens lacking HSF4. Hsf4 is essential for lens development. Newborn Mouse lens expression pattern of HSF4-/- and wildtype.
ORGANISM(S): Mus musculus 
2009-08-11 | E-GEOD-12415 | biostudies-arrayexpress
UnknownThe Pregnancy in Polycystic Ovary Syndrome II (PPCOS II) trial: rationale and design of a double-blind randomized trial of clomiphene citrate and letrozole for the treatment of infertility in women with polycystic ovary syndrome.
Not available
S-EPMC3312939 | biostudies-literature
UnknownLetrozole versus clomiphene for infertility in the polycystic ovary syndrome.
Not available
S-EPMC4175743 | biostudies-literature
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