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GenomicsThe Hsp90 cochaperone TTT promotes cotranslational maturation of PIKK kinases prior to complex assembly
The Hsp90 cochaperone TTT promotes cotranslational maturation of PIKK kinases prior to complex assembly
PRJNA761401 | ENA
ProteomicsThe Hsp90 cochaperone TTT promotes cotranslational maturation of PIKK kinases prior to complex assembly
PIKKs are a family of kinases that control fundamental processes, including cell growth, DNA damage repair, and gene expression. Although their regulation and activities are well characterized, little is known about how PIKKs fold and assemble into active complexes. Previous work identified an Hsp90...
ORGANISM(S): Schizosaccharomyces pombe 972h- 
2021-09-10 | PXD028351 | Pride
Multimeric complex Chaperone Translation Pikk kinases 
GenomicsEffect of depleting GNB1L on PIKK mRNA levels to explore the regulatory mechanism of GNB1L on PIKK proteins
Effect of depleting GNB1L on PIKK mRNA levels to explore the regulatory mechanism of GNB1L on PIKK proteins
PRJNA985459 | ENA
TranscriptomicsEffect of depleting GNB1L on PIKK mRNA levels to explore the regulatory mechanism of GNB1L on PIKK proteins
Our screens identified GNB1L, a high-confidence hit, as a novel positive regulator of DDR signaling. We therefore generated HEK293A-GNB1L-dTAG cells which the GNB1L-dTAG-HA protein decreased to markedly lower levels in the presence of dTAGv-1 than that in cells treated with dTAG-NEG , we next examin...
ORGANISM(S): Homo sapiens 
2023-06-23 | GSE235200 | GEO
TranscriptomicsThe Hsp90 cochaperone TTT promotes cotranslational maturation of PIKK kinases prior to complex assembly
PIKKs are a family of kinases that control fundamental processes, including cell growth, DNA damage repair, and gene expression. Although their regulation and activities are well characterized, little is known about how PIKKs fold and assemble into active complexes. Previous work identified an Hsp90...
ORGANISM(S): Schizosaccharomyces pombe 
2021-09-10 | GSE183610 | GEO
ProteomicsChemoproteomic selectivity profiling of PIKK and PI3K kinase inhibitors
"Here, we report the development of a novel version of Kinobeads that extends kinome coverage to PIKK and PI3K kinases. This is achieved by inclusion of two affinity probes derived from the clinical PI3K/MTOR inhibitors Omipalisib and BGT226. The new affinity matrix was used to profile 13 clinical a...
ORGANISM(S): Homo sapiens (Human) 
2019-03-29 | PXD011719 | Pride
Chemoproteomics" "kinobeads Drug profiling 
UnknownInhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK).
Not available
S-EPMC10392309 | biostudies-literature
UnknownNMR- and circular dichroism-monitored lipid binding studies suggest a general role for the FATC domain as membrane anchor of phosphatidylinositol 3-kinase-related kinases (PIKK).
Not available
S-EPMC3707702 | biostudies-literature
UnknownTTT and PIKK Complex Genes Reverted to Single Copy Following Polyploidization and Retain Function Despite Massive Retrotransposition in Maize.
Not available
S-EPMC5681926 | biostudies-literature
UnknownThe phosphoinositide-3-OH-kinase-related kinases of Arabidopsis thaliana.
Not available
S-EPMC1369146 | biostudies-literature
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