Germline mutations are the source of evolution and contribute substantially to many health-related processes. In this study, we use whole genome deep sequencing data from parents-offspring trios to examine the de novo point mutations (DNMs) in the offspring.
RNA-seq of post-mort retina donor without clinically relevant visual impairment. Ploy-A enriched. 75-nt paired-end. Short time lapse between tissue sampling and cDNA generation.
