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TranscriptomicsTranscription profiling of human skeletal muscle of PCOS patients after pioglitazone therapy
Insulin resistance is a common metabolic abnormality in women with PCOS and leads to an elevated risk of type 2 diabetes. Studies have shown that thiazolidinediones (TZD) improve metabolic disturbances in PCOS patients. We hypothesized that the effect of TZD in PCOS is in part mediated by changes in...
ORGANISM(S): Homo sapiens 
2008-11-14 | E-GEOD-8157 | biostudies-arrayexpress
TranscriptomicsThe peroxisome proliferator-activated receptor-gamma agonist pioglitazone modulates aberrant T cell responses in systemic lupus erythematosus
Previous studies indicate that peroxisome proliferator-activated receptor-gamma (PPAR-g) agonists suppress autoimmune responses and renal inflammation in murine lupus. However, the mechanisms implicated in this process remain unclear. We tested the effect of the PPAR-g agonist pioglitazone in human ...
ORGANISM(S): Homo sapiens 
2014-12-08 | E-GEOD-45923 | biostudies-arrayexpress
TranscriptomicsEffect of pioglitazone treatment on gene expression in NCI-H2347 lung cancer cells: time course experiment
Microarray studies was performed to analyze gene expression changes in NCI-H2347 cells after treatment with 50 µM pioglitazone for 12hr, 24hr and 48hrs. RNA samples, containing 3 replicates for each sample, were extracted from NCI-H2347 cells after treatment with pioglitazone or vhicle (DMSO) for...
ORGANISM(S): Homo sapiens 
2014-09-25 | E-GEOD-59735 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse 3T3-L1 cells treated 24 hours with either 0.1% DMSO, 20uM pioglitazone, 1uM rosiglitazone or 20uM troglitazone
3T3-L1 cells treated 24 hours with either 0.1% DMSO, 20uM pioglitazone, 1uM rosiglitazone or 20uM troglitazone
ORGANISM(S): Mus musculus 
2007-10-09 | E-GEOD-1458 | biostudies-arrayexpress
TranscriptomicsApoptosis rate and transcriptional response of pancreatic islets exposed to the PPAR gamma agonist Pioglitazone
To explore the molecular pathways underlying thiazolidinediones effects on pancreatic islets in conditions mimicking normo- and hyperglycemia, apoptosis rate and transcriptional response to Pioglitazone at both physiological and supraphysiological glucose concentrations were evaluated. Adult rat isl...
ORGANISM(S): Mus musculus 
2012-08-16 | E-GEOD-40119 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of patient-derived xenograft models of myxoid liposarcoma either responsive or resistant to trabectedin treatment.
Transcriptional profiling of patient-derived xenograft models of myxoid liposarcoma with either FUS-CHOP type I, named as ML017, or FUS-CHOP type III, named as ML006. Both ML017 and ML006 are responsive to trabectedin treatment, while model ML017/ET has aquired resistance to the drug. Samples are ei...
ORGANISM(S): Homo sapiens 
2020-01-10 | E-MTAB-8632 | biostudies-arrayexpress
ProteomicsAntidiabetic PPARγ Antidiabetic PPARγ agonist Pioglitazone inhibits cell proliferation and induces metabolic reprogramming in prostate cancer cellsonist Pioglitazone inhibits cell proliferation and induces metabolic reprogramming in prostate cancer cells
Background: Prostate cancer (PCa) and Type 2 diabetes (T2D) are two major health risks that often occur concurrently in men. Studies predict that diabetic PCa patients have a reduced risk of PCa progression, while other studies show contradicting data. This impedes unraveling the connection between ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-11 | PXD060526 | Pride
Prostate cancer cells  ppar agonists  proteome and metabolic reprogramming 
TranscriptomicsTranscription profiling of mouse adipocytes after telmisartan, pioglitazone or irbesartan treatment
expression pattern of adipocytes after telmisartan, pioglitazone or irbesartan treatment
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-2486 | biostudies-arrayexpress
TranscriptomicsA systems biology approach to understand the pathophysiological mechanisms of cardiac pathological hypertrophy associated with rosiglitazone
Cardiac pathological hypertrophy is associated with a significantly increased risk of coronary heart disease and has been observed in diabetic patients treated with rosiglitazone, whereas most published studies do not suggest a similar increase in risk of cardiovascular events in pioglitazone-treate...
ORGANISM(S): Mus musculus 
2014-06-30 | E-GEOD-48977 | biostudies-arrayexpress
GenomicsEffects of pioglitazone and beta-naphtoflavone on human primary trophoblasts
Effects of pioglitazone and beta-naphtoflavone on human primary trophoblasts
PRJNA407903 | ENA
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