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TranscriptomicsRNA-Seq of human regulatory T cells and effector T cells cultured at standard 37C temperature and in mild hypothermia (33C).
Regulatory T cells (Tregs) play crucial role in maintenance of peripheral tolerance. Numerous clinical trials confirmed safety and efficacy of Treg treatment of for deleterious immune responses. However, Tregs lose their characteristic phenotype and suppressive potential during expansion ex vivo. In...
ORGANISM(S): Homo sapiens 
2017-10-04 | E-MTAB-5322 | biostudies-arrayexpress
TranscriptomicsRegeneration of comparative genomic hybridization oligonucleotide microarrays with dimethylurea
Reuse of materials in DNA hybridization based methods has been known since the advent of Southern membranes. Array based comparative genomic hybridization is essentially Southern hybridization with multiple probes immobilized on a solid surface. We have shown that comparative genomic hybridization m...
ORGANISM(S): Homo sapiens 
2012-05-22 | E-GEOD-35740 | biostudies-arrayexpress
TranscriptomicsNGS_Schwannomatosis_2012
Targeted resequencing of chromosome 22 in schwannomatosis individuals
ORGANISM(S): Homo sapiens 
2013-11-12 | E-MTAB-1574 | biostudies-arrayexpress
TranscriptomicsSomatic mosaicism for copy number variation in differentiated human tissues
Genetic variation is responsible for the generation of phenotypic diversity, including susceptibility to disease. Two major types of variation are known: single nucleotide polymorphisms (SNPs) and a more recently discovered structural variation, involving changes in copy number (CNVs) of kilobase- t...
ORGANISM(S): Homo sapiens 
2008-09-16 | E-GEOD-9598 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human BR.1N and HaCaT cell lines treated with zebularine against untreated controls
The experimental design demonstrates that zebularine, a DNA methyltransferase inhibitor, promotes regeneration in the mouse and that retinoic acid and zebularine synergistically accelerate this process.
ORGANISM(S): Homo sapiens 
2019-11-02 | E-MTAB-6832 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human ASCs expanded with 10% FBS and in FBS-deprived condition
In this experiment we determined the effects of FBS supplementation and subsequent deprivation (after second passage) on the whole transcriptome, including comprehensive mRNA and miRNA profiling.
ORGANISM(S): Homo sapiens 
2018-08-09 | E-MTAB-6436 | biostudies-arrayexpress
GenomicsConcurrent DNA copy number alterations and mutations in genes related to maintenance of genome stability in uninvolved glandular tissue from breast cancer patients.
Somatic mosaicism for DNA copy number alterations (SMC-CNA) is defined as gain or loss of chromosomal segments in mitotic cells within a single organism. As cells harboring SMC-CNA have the potential to undergo clonal expansion, SMC-CNA may be present in a substantial portion of cells in differentia...
ORGANISM(S): Homo sapiens 
2015-07-31 | E-MTAB-3110 | biostudies-arrayexpress
GenomicsGenotyping BRCA1 and BRCA2 in genomically unstable glandular tissue from breast cancer patients.
Somatic mosaicism for DNA copy number alterations (SMC-CNA) is defined as gain or loss of chromosomal segments in mitotic cells within a single organism. As cells harboring SMC-CNA have the potential to undergo clonal expansion, SMC-CNA may be present in a substantial portion of cells in differentia...
ORGANISM(S): Homo sapiens 
2015-07-31 | E-MTAB-3111 | biostudies-arrayexpress
TranscriptomicsConcurrent DNA copy number alterations and mutations in genes related to maintenance of genome stability in uninvolved glandular tissue from breast cancer patients
Somatic mosaicism for DNA copy number alterations (SMC-CNA) is defined as gain or loss of chromosomal segments in mitotic cells within a single organism. As cells harboring SMC-CNA have the potential to undergo clonal expansion, SMC-CNA may be present in a substantial portion of cells in differentia...
ORGANISM(S): Homo sapiens 
2015-07-30 | E-GEOD-63623 | biostudies-arrayexpress
TranscriptomicsmiRNA-seq of human ASCs expanded with 10% FBS and in FBS-deprived condition.
In this experiment we determined the effects of FBS supplementation and subsequent deprivation (after second passage) on the whole transcriptome, including comprehensive mRNA and miRNA profiling.
ORGANISM(S): Homo sapiens 
2018-08-09 | E-MTAB-6390 | biostudies-arrayexpress
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