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TranscriptomicsComparative Effects of Statins on Murine Cardiac Gene Expression Profiles in Normal Mice
Recent clinical data suggest that the efficacy of statin treatment in patients with heart failure varies depending on the drugs administered. Therefore, the present study was undertaken to compare murine cardiac gene expression following treatment with four different statins. Statins directly regula...
ORGANISM(S): Mus musculus 
2013-03-31 | E-GEOD-23101 | biostudies-arrayexpress
TranscriptomicsExpression data of HUVEC cells after statin treatment
3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, statins, are known to exert endothelial athero-protective effects through the induction of specific transcriptional factors and their downstream target genes besides lowering LDL-cholesterol. However its critical mechanism has not still be...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-32547 | biostudies-arrayexpress
TranscriptomicsExpression data of statin treated HUVEC cells transfected siRNA KLF2 or KLF4.
KLF2 and KLF4 are important transcriptional factors in endothelial cells, however their roles in statin treatment has not been elucidated. Here we report the comprehensive change of transcripts of statin treated HUVECs transfected with siRNA KLF2 or KLF4. We used repeated microarray analysis of HUV...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-32693 | biostudies-arrayexpress
GenomicsRNA-seq in CUTLL3 cell line treated with Vehicle or Pitavastatin
RNA-seq in CUTLL3 cell line treated with Vehicle or Pitavastatin
PRJNA692465 | ENA
GenomicsH3K27acetylation ChIP-seq in CUTLL3 cell line treated with Vehicle or Pitavastatin
H3K27acetylation ChIP-seq in CUTLL3 cell line treated with Vehicle or Pitavastatin
PRJNA692467 | ENA
GenomicsCombined pitavastatin and capmatinib inhibits tumor growth though completed shutdown of MET signal
Combined pitavastatin and capmatinib inhibits tumor growth though completed shutdown of MET signal
PRJNA607759 | ENA
GenomicsmRNA expression profile in HeLa cells that subject to pitavastatin treantment.
mRNA expression profile in HeLa cells that subject to pitavastatin treantment.
PRJNA821489 | ENA
GenomicsGenome-wide maps of MEF2C and H3K27ac localization in HUVECs
MEF2C is one of the substantially expressed transcriptional factors in endothelial cells, but its genomic localization is unknown. This time, we established a new antibody for MEF2C, and performed ChIP-seq to identify MEF2C binding site in whole genome manner. H3K27Ac binding sites were also detec...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-32644 | biostudies-arrayexpress
TranscriptomicsCombined pitavastatin and capmatinib inhibits tumor growth though completed shutdown of MET signal
To reveal the function of pitavastatin in cancer, we performed several experiments. In the present study, we show that pitavastatin inhibits the tumor growth through the inactivation of ERK and AKT signals by MET immaturation, and combination of pitavastatin and capmatinib, a MET inhibitor, might be...
ORGANISM(S): Homo sapiens 
2021-02-19 | GSE145624 | GEO
GenomicsExpression profiling of pitavastatin in a tumor-immune model in vitro
Expression profiling of pitavastatin in a tumor-immune model in vitro
PRJNA854630 | ENA
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