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MetabolomicsIntegrated proteomic and metabolomic profiling reveals molecular signatures underlying invasiveness in non-functioning pituitary adenomas

Pituitary adenomas constitute 10 to 25% of intracranial tumors, rendering them one of the most prevalent types of brain tumors. While the majority of pituitary adenomas are benign, ~35% exhibit invasive behavior. Compared with their non-invasive counterparts, invasive pituitary adenomas are more ...

2025-12-09 | MTBLS13478 | MetaboLights
MetabolomicsExploring the gut microbiome and serum metabolome interplay in non-functioning pituitary neuroendocrine tumors.

The gut microbiome has emerged as a potential factor in cancer pathogenesis, but its role in non-functioning pituitary neuroendocrine tumors (NF-PitNETs) remains unclear. This study aimed to elucidate gut microbiome and metabolomic alterations in NF-PitNETs by comparing microbial diversity, patho...

2025-06-16 | MTBLS12328 | MetaboLights
TranscriptomicsmicroRNA profiling of female and male mouse pituitary gland across pubertal transition
The pituitary gland exhibits sex differences in its function. Diseases associated with dysregulation of the pituitary are also sex-biased in prevalence. Previous qPCR profiling of puberty-related genes in the pituitary gland revealed increasingly sex-biased expression of genes profiled across pubert...
ORGANISM(S): Mus musculus 
2022-10-12 | E-MTAB-9460 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of gonadotrope pituitary tumors identifies Growth arrest and DNA-damage-inducible gene beta (GADD45beta) as a Novel Tumor Suppressor in Pituitary Gonadotrope Tumors
Gonadotrope or null cell pituitary tumors present clinically with signs of hypogonadism and hypopituitarism, together with visual disturbances due to mass effects. Since there are no medical therapies, surgery and/or radiation are the only therapeutic options. To identify dysregulated genes and/or...
ORGANISM(S): Homo sapiens 
2011-01-31 | E-GEOD-26966 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human pituitary adenomas
This series includes the four major subtypes of pituitary adenomas and normal post-mortem pituitary tissue; Data Transformation; Using Affymetrix Microarray Suite 5.0 global scaling was applied to the quantification data to adjust the average recorded to a target intensity of 100. Data were then exp...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2175 | biostudies-arrayexpress
ProteomicsProteomic Blueprint of the Pituitary anterior and posterior lobes for better understanding of the physiology of pituitary gland.
This study provides a comprehensive proteomic analysis of five matched pairs of the anterior and posterior lobe of the pituitary, which was used to study the proteomic signature specific to both anterior and posterior lobes.
ORGANISM(S): Homo Sapiens 
2022-12-06 | PXD029991 | panorama
ProteomicsUnderstanding early AutoAb signatures in Pituitary Adenomas using CDI HuProt™ (Human Proteome Microarray)
CDI HuProt™ (Human Proteome Microarray), was used to study Pituitary Adenomas PAs (Acromegaly, Cushing's and NFPA) using serum samples, from around 14 individuals (4 Healthy control, 4 Acromegaly, 3 Cushing’s and 3 NFPAs patient samples) were used study their autoantibody profiles. Patient serum sam...
ORGANISM(S): Homo sapiens 
2022-09-30 | E-MTAB-11947 | biostudies-arrayexpress
TranscriptomicsDioxin effect on the pituitary and hypothalamic expression of genes in male fetal Wistar rats
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) causes the many forms of reproductive toxicity, such as defects in sexual behaviors, in pups of which mother is exposed to this substance at lower doses. However, the mechanism underlying these defects remains to be clarified in spite of many researches con...
ORGANISM(S): Rattus norvegicus 
2011-09-30 | E-GEOD-32459 | biostudies-arrayexpress
TranscriptomicsEffect of maternal exposure to dioxin on the pituitary and hypothalamic expression of genes in PND70 male pups
Our previous studies have revealed that treatment of pregnant rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, 1 M-NM-
ORGANISM(S): Rattus norvegicus 
2013-08-21 | E-GEOD-48100 | biostudies-arrayexpress
TranscriptomicsIntegrative miRnome and transcriptome analysis in human malignant prolactin pituitary tumors identify miR-183 as driving gene for tumor progression to malignancy.
miRNAs expression is known to be deregulated in many types of cancer leading to suspect them implication in crucial steps occurring during tumor progression and maybe as potential driving genes. In this study we tried to decipher the place of miRNA in the hierarchical events cascade occurring in pr...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-46294 | biostudies-arrayexpress
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