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MetabolomicsExploring the gut microbiome and serum metabolome interplay in non-functioning pituitary neuroendocrine tumors.

The gut microbiome has emerged as a potential factor in cancer pathogenesis, but its role in non-functioning pituitary neuroendocrine tumors (NF-PitNETs) remains unclear. This study aimed to elucidate gut microbiome and metabolomic alterations in NF-PitNETs by comparing microbial diversity, patho...

2025-06-16 | MTBLS12328 | MetaboLights
TranscriptomicsmicroRNA profiling of female and male mouse pituitary gland across pubertal transition
The pituitary gland exhibits sex differences in its function. Diseases associated with dysregulation of the pituitary are also sex-biased in prevalence. Previous qPCR profiling of puberty-related genes in the pituitary gland revealed increasingly sex-biased expression of genes profiled across pubert...
ORGANISM(S): Mus musculus 
2022-10-12 | E-MTAB-9460 | biostudies-arrayexpress
TranscriptomicsSexually dimorphic gene expression in the hypothalamus, pituitary gland and cortex by SAGE
C57BL6 mice (12-15 weeks old) were obtained from Charles River Laboratories (St. Constant, Québec). They were housed in an air-conditioned room (19-25Åé) with controlled lighting from 07:15 to 19:15 h and were given free access to laboratory chow (Lab Rodent Diet No. 5002, Ren’s Feed and Suppliers, ...
ORGANISM(S): Mus musculus 
2006-01-13 | E-GEOD-2156 | biostudies-arrayexpress
ProteomicsProteomic Blueprint of the Pituitary anterior and posterior lobes for better understanding of the physiology of pituitary gland.
This study provides a comprehensive proteomic analysis of five matched pairs of the anterior and posterior lobe of the pituitary, which was used to study the proteomic signature specific to both anterior and posterior lobes.
ORGANISM(S): Homo Sapiens 
2022-12-06 | PXD029991 | panorama
Transcriptomics3'-UTR-seq of female and male mouse pituitary gland across pubertal transition
The pituitary gland exhibits sex differences in its function. Diseases associated with dysregulation of the pituitary are also sex-biased in prevalence. Previous qPCR profiling of puberty-related genes in the pituitary gland revealed increasingly sex-biased expression of genes profiled across pubert...
ORGANISM(S): Mus musculus 
2022-10-12 | E-MTAB-9459 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat anterior pituitary gland response to diethylstilbestrol
This SuperSeries is composed of the following subset Series:; GSE4028: Effects of diethylstilbestrol (DES) on the anterior pituitary gland of the ACI, Copenhagen and Brown Norway Rat. GSE4080: Effect of DES-treated Ept congenic rat lines on gene expression in the anterior pituitary gland. GSE4081: E...
ORGANISM(S): Rattus norvegicus 
2008-06-12 | E-GEOD-4083 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of gonadotrope pituitary tumors identifies Growth arrest and DNA-damage-inducible gene beta (GADD45beta) as a Novel Tumor Suppressor in Pituitary Gonadotrope Tumors
Gonadotrope or null cell pituitary tumors present clinically with signs of hypogonadism and hypopituitarism, together with visual disturbances due to mass effects. Since there are no medical therapies, surgery and/or radiation are the only therapeutic options. To identify dysregulated genes and/or...
ORGANISM(S): Homo sapiens 
2011-01-31 | E-GEOD-26966 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat anterior pituitary gland using DES-treated COPxACI F2 rats - Expression QTL mapping.
Anterior pituitary glands were isolated from 21 week old male rats treated for 12 weeks with the synthetic estrogen diethylstilbestrol (DES). 43 COPxACI F2 animals were selected based on pituitary weight phenotypic extremes: 22 highest and 21 lowest pituitary weights in our F2 population. Expression...
ORGANISM(S): Rattus norvegicus 
2008-06-12 | E-GEOD-4081 | biostudies-arrayexpress
TranscriptomicsRNA-seq of the pituitary gland of male rats exposed to stress against unexposed controls
Environmental stressors such as repeated social defeat may trigger powerful activation of sub-conscious parts of the brain. We examine the consequences of such stress in male rats on the pituitary gland. We prepared 20 Sprague Dawley rats. 10 of them were exposed to stress induced by the resident-in...
ORGANISM(S): Rattus norvegicus 
2022-08-03 | E-MTAB-11285 | biostudies-arrayexpress
ProteomicsUnderstanding early AutoAb signatures in Pituitary Adenomas using CDI HuProt™ (Human Proteome Microarray)
CDI HuProt™ (Human Proteome Microarray), was used to study Pituitary Adenomas PAs (Acromegaly, Cushing's and NFPA) using serum samples, from around 14 individuals (4 Healthy control, 4 Acromegaly, 3 Cushing’s and 3 NFPAs patient samples) were used study their autoantibody profiles. Patient serum sam...
ORGANISM(S): Homo sapiens 
2022-09-30 | E-MTAB-11947 | biostudies-arrayexpress
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