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TranscriptomicsRegulatory function of Pja2 mediated by the P2rx3/P2rx7 axis in mouse hippocampal neuronal cells
Praja2 (Pja2), a member of the growing family of mammalian RING E3 ubiquitin ligases, is reportedly involved not only in several types of cancer but also in neurological diseases and disorders. However, the underlying genetic mechanism of Pja2 regulation in the nervous system remains unclear. To stu...
ORGANISM(S): Mus musculus 
2020-12-15 | E-MTAB-6464 | biostudies-arrayexpress
GenomicsGene expression changes induced by overexpression of PJA2 in SW-480 cells
Gene expression changes induced by overexpression of PJA2 in SW-480 cells
PRJNA1039483 | ENA
TranscriptomicsGene expression changes induced by overexpression of PJA2 in SW-480 cells
To investigate the impact of PJA2 on the progression of colorectal cancer, we employed lentiviral constructs to establish PJA2-overexpressing SW-480 cell lines. Subsequently, we conducted gene expression profiling analysis using RNA-seq data obtained from both vector SW-480 cells and PJA2-overexpres...
ORGANISM(S): Homo sapiens 
2024-08-30 | GSE247535 | GEO
GenomicsRegulatory function of Pja2 mediated by the P2rx3/P2rx7 axis in mouse hippocampal neuronal cells
Regulatory function of Pja2 mediated by the P2rx3/P2rx7 axis in mouse hippocampal neuronal cells
PRJNA431744 | ENA
GenomicsRegulatory function of Pja2 mediated by the P2rx3/P2rx7 axis in mouse hippocampal neuronal cells
Regulatory function of Pja2 mediated by the P2rx3/P2rx7 axis in mouse hippocampal neuronal cells
PRJEB30996 | ENA
TranscriptomicsRegulatory function of Pja2 mediated by the P2rx3/P2rx7 axis in mouse hippocampal neuronal cells
A member of the growing family of mammalian RING E3-ubiquitin ligases praja2 (Pja2) was reported to function not only in several types of cancer but also in the neurological diseases and disorders. As a result, the expression of App, Mapt and Gsap could be inhibited by Pja2 overexpression and activa...
ORGANISM(S): Mus musculus 
2020-04-25 | GSE109699 | GEO
UnknownPJA2 Suppresses Colorectal Cancer Progression by Controlling HDAC2 Degradation and Stability.
Not available
S-EPMC11967759 | biostudies-literature
UnknownRole of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation.
Not available
S-EPMC4107453 | biostudies-literature
UnknownELK4 promotes the development of gastric cancer by inducing M2 polarization of macrophages through regulation of the KDM5A-PJA2-KSR1 axis.
Not available
S-EPMC8353876 | biostudies-literature
UnknownPJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription.
Not available
S-EPMC5366948 | biostudies-literature
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