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TranscriptomicsTranscription profiling of mouse PKBalpha-/-thymus reveals deletion of PKBalpha/Akt1 affects thymic development
The thymus constitutes the primary lymphoid organ for the majority of T cells. The phosphatidyl-inositol 3 kinase (PI3K) signaling pathway is involved in lymphoid development. Defects in single components of this pathway prevent thymocytes from progressing beyond early T cell developmental stages. P...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7875 | biostudies-arrayexpress
TranscriptomicsModulation of glutamine metabolism by the PI3K-PKB/c-akt-FOXO network regulates autophagy
This SuperSeries is composed of the following subset Series: GSE35701: CP001: Modulation of glutamine metabolism by the PI3K-PKB/c-akt-FOXO network regulates autophagy GSE35703: CP003: Modulation of glutamine metabolism by the PI3K-PKB/c-akt-FOXO network regulates autophagy Refer to individual Serie...
ORGANISM(S): Mus musculus 
2012-07-21 | E-GEOD-35705 | biostudies-arrayexpress
ProteomicsIdentification of PKB substrates in the liver
This study was to identify novel PKB substrates in mouse liver through immunoprecipitation with PAS antibody.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-07-19 | MSV000087849 | MassIVE
TranscriptomicsCP001: Modulation of glutamine metabolism by the PI3K-PKB/c-akt-FOXO network regulates autophagy
The PI3K-PKB/c-akt-FOXO signalling network provides a major intracellular hub for regulation of cell proliferation, survival and stress resistance1. Here we report a novel function for FOXO transcription factors in regulating autophagy through modulation of intracellular glutamine levels. To identif...
ORGANISM(S): Mus musculus 
2012-07-21 | E-GEOD-35701 | biostudies-arrayexpress
TranscriptomicsAsymmetric cancer cell division regulated by AKT, Reactive Oxygen Species (ROS) high versus ROS low mRNA
Human tumors often contain slowly proliferating cancer cells that resist treatment but we do not know precisely how these cells arise. We show that rapidly proliferating cancer cells can divide asymmetrically to produce slowly proliferating “G0-like” progeny that are enriched following chemotherapy ...
ORGANISM(S): Homo sapiens 
2011-07-14 | E-GEOD-30465 | biostudies-arrayexpress
TranscriptomicsCP003: Modulation of glutamine metabolism by the PI3K-PKB/c-akt-FOXO network regulates autophagy
The PI3K-PKB/c-akt-FOXO signalling network provides a major intracellular hub for regulation of cell proliferation, survival and stress resistance1. Here we report a novel function for FOXO transcription factors in regulating autophagy through modulation of intracellular glutamine levels. To identif...
ORGANISM(S): Mus musculus 
2012-07-21 | E-GEOD-35703 | biostudies-arrayexpress
TranscriptomicsComparison of Differences in Mouse Mammary gland gene expression data at POSTNATAL DAY 70 in Akt1wildtype versus Akt1-deficient mice
Akt1, a serine-threonine protein kinase member of the PKB/Akt gene family, plays a critical role in the regulation of several cellular processes including cell proliferation and apoptosis. In this study, we utilized Akt1+/+ and Akt1¬-/- C57/Bl6 female mice to demonstrate that Akt1 is required for n...
ORGANISM(S): Mus musculus 
2011-07-14 | E-GEOD-30671 | biostudies-arrayexpress
UnknownIn vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis.
Not available
S-EPMC2662067 | biostudies-literature
TranscriptomicsCP003: Modulation of glutamine metabolism by the PI3K-PKB/c-akt-FOXO network regulates autophagy
The PI3K-PKB/c-akt-FOXO signalling network provides a major intracellular hub for regulation of cell proliferation, survival and stress resistance1. Here we report a novel function for FOXO transcription factors in regulating autophagy through modulation of intracellular glutamine levels. To identif...
ORGANISM(S): Mus musculus 
2012-07-22 | GSE35703 | GEO
TranscriptomicsCP001: Modulation of glutamine metabolism by the PI3K-PKB/c-akt-FOXO network regulates autophagy
The PI3K-PKB/c-akt-FOXO signalling network provides a major intracellular hub for regulation of cell proliferation, survival and stress resistance1. Here we report a novel function for FOXO transcription factors in regulating autophagy through modulation of intracellular glutamine levels. To identif...
ORGANISM(S): Mus musculus 
2012-07-22 | GSE35701 | GEO
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