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GenomicsPKD Labrador Study
Discovery of variants that segregate with PKD
PRJEB34050 | ENA
TranscriptomicsTranscription profiling of rat kidney from male and female heterozygous PKD/Mhm and wild type animals
Gender has strong impact on kidney performance. Female gender tends to be renal protective. PKD/Mhm is rat model for human polycystic kidney disease (PKD) caused by a mutation in gene Anks6. PKD progresses faster in male rats compared with females. We used microarrays to detect gender-dependent gene...
ORGANISM(S): Rattus norvegicus 
2009-10-11 | E-GEOD-13065 | biostudies-arrayexpress
TranscriptomicsExpression data from kidney of 36d old PKD/Mhm rats.
Gender has strong impact on kidney performance. Female gender tends to be renal protective. PKD/Mhm is rat model for human polycystic kidney disease (PKD) caused by a mutation in gene Anks6. PKD progresses faster in male rats compared with females. We used microarrays to detect gender-dependent gene...
ORGANISM(S): Rattus norvegicus 
2009-09-30 | GSE13065 | GEO
GenomicsRNA-sequencing of renal cells from Setd2-wildtype PKD and Setd2-knlckout ccRCC mice.
RNA-sequencing of renal cells from Setd2-wildtype PKD and Setd2-knlckout ccRCC mice.
PRJNA913096 | ENA
TranscriptomicsRNA-sequencing of renal cells from Setd2-wildtype PKD and Setd2-knlckout ccRCC mice.
To explore potential role of SETD2 in PKD-ccRCC transition in vivo, we generated a PKD mouse model by overexpressing oncogene c-MYC under the control of the Ksp promoter (KM mice), and knockout Setd2 gene using the same Ksp promoter in this PKD mice (KMs mice) to establish a ccRCC mouse model. To fu...
ORGANISM(S): Mus musculus 
2022-12-26 | GSE221136 | GEO
Unknownp53 mutation regulates PKD genes and results in co-occurrence of PKD and tumorigenesis.
Not available
S-EPMC6528458 | biostudies-literature
UnknownDiscoidin Domain Receptor 1 (DDR1) tyrosine kinase is upregulated in PKD kidneys but does not play a role in the pathogenesis of polycystic kidney disease.
Not available
S-EPMC6602183 | biostudies-literature
ProteomicsAdipose tissue protein kinase D (PKD): regulation of signalling networks and its effect on metabolism
The protein kinase D (PKD) family of three highly homologous isoforms (PKD1, PKD2, and PKD3) are implicated as nutrient sensing signalling kinases that regulate the response of adipose and other tissues to the nutrient environment. However, the physiological role of adipose tissue PKD and the cellul...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-27 | PXD056412 | Pride
Human Adipose tissue Phosphoproteomics 
UnknownApoptosis and autophagy in polycystic kidney disease (PKD).
Not available
S-EPMC7127985 | biostudies-literature
UnknownMore dissimilarities than affinities between DNAJB11-PKD and ADPKD.
Not available
S-EPMC9155219 | biostudies-literature
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