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ProteomicsZapnometinib treatment and influenza A virus infection induce alteration on the HLA class I ligandome of human lung adenocarcinoma cells
Targeting cellular factors is considered a promising approach to combat viral infection and overcome the resistance issue associated with direct-acting antiviral (DAA) drugs administration. In the context of drug repurposing strategies, we have previously explored the antiviral efficacy of the MEK i...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD041578 | Pride
Influenza a virus Ligandome analysis Mek inhibitors Zapnometinib Mhc-i Lc-ms/ms 
ProteomicsIdentification of naturally-presented influenza A virus CD8+ T cell epitopes
Influenza viruses (IV) infection is a public health concern worldwide. Currently, all available vaccines as well as antiviral drugs that target the virus itself are prone to resistance. Lessons learned from previous pandemic outbreaks is that people with a preexisting cellular immune response are ei...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD035241 | Pride
Influenza a virus Ligandome analysis Cd8+ t cell T cell epitopes 
ProteomicsA tissue-based draft map of the murine MHC class I immunopeptidome
The array of peptides presented to CD8+ T cells by major histocompatibility complex (MHC) class I molecules is referred to as the MHC class I immunopeptidome. Although the MHC class I immunopeptidome is ubiquitous in mammals and represents a critical component of the adaptive immune system, very lit...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-19 | MSV000084980 | MassIVE
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