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MetabolomicsMembrane lipid as cofactor of cargo uptake and release by box-like lipid transfer proteins
Lipid transfer proteins (LTPs) shuttle their cargo lipids between cellular membranes. LTPs facilitate the costly extraction of a lipid from a donor membrane, and its delivery into the acceptor membrane, but the mechanisms remain poorly understood. We combined extensive molecular dynamics simulations...
2026-10-06 | MTBLS15933 | MetaboLights
MetabolomicsDeficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2...
2018-01-25 | MTBLS600 | MetaboLights
MetabolomicsInterorganelle lipid flux revealed by enzymatic mass tagging in vivo
The distinct activities of cellular organelles are dependent on the proper function of their membranes. Coordinated membrane biogenesis of the different organelles necessitates interorganelle transport of lipids from their site of synthesis to their destination membranes. Several proteins and traffi...
2022-03-22 | MTBLS3415 | MetaboLights
Metabolomics1H NMR-Based Plasma Metabolomics and Machine Learning Reveal Distinct Metabolic Signatures of Breast Cancer in Nigerian Women

Metabolic dysregulation is a hallmark of cancer and provides insights into biomarker discovery. Untargeted 1H NMR metabolomics offers a non-invasive means to identify biomarkers in breast cancer (BC) patients; however, metabolic signatures specific to Nigerian women remain poorly understood. This...

2026-02-23 | MTBLS13829 | MetaboLights
MetabolomicsCD36 palmitoylation regulates the lipid metabolic homeostasis

Alterations in myocardial energy substrate metabolism following myocardial infarction (MI) results in structural and functional abnormalities of the heart. The fatty acid translocase CD36 (CD36), acrucial membrane protein, plays a pivotal role in regulating fatty acid (FA) uptake and lipid homeos...

2025-06-15 | MTBLS12600 | MetaboLights
MetabolomicsATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

The induction of endoplasmic reticulum unfolded protein responses (UPRER) contributes to cancer development and progression. We recently linked microbiota-related triggers to the tumor-promoting role of signal transducer activating transcription factor 6 (ATF6) in the colon. Here we substantiate ...

2025-07-02 | MTBLS7387 | MetaboLights
ProteomicsChanges in golden Syrian hamster HDL proteome caused by altered cholesteryl ester transfer protein expression
Cholesteryl ester transfer protein (CETP) transfers cholesteryl ester (CE) and triglyceride (TG) between lipoproteins, which alters lipoprotein metabolism. Hamster and human CETPs have very different preferences for CE versus TG as substrate. To assess the impact of altering CETP’s substrate prefere...
ORGANISM(S): Mesocricetus auratus (Golden hamster) 
2020-06-25 | PXD017998 | Pride
High density lipoprotein Hamster Plasma Cholesteryl ester transfer protein Lc-ms/ms 
TranscriptomicsMicroarray gene expression analysis on the liver of spontaneously hypertensive rats (SHR) transgenic for human cholesteryl ester transfer protein
To explore the impact of cholesteryl ester transfer protein (CETP) gene on atherosclerosis-associated phenotypes, we newly generate a human CETP-transgenic (Tg[hCETP]) strain of the genetic background of spontaneously hypertensive rat (SHR). Microarray gene expression analysis was performed on the l...
ORGANISM(S): Rattus norvegicus 
2020-01-14 | E-MTAB-7861 | biostudies-arrayexpress
MetabolomicsLipidCreator workbench to probe the lipidomic landscape - Platelet isolation and stimulation - DIA lipid mediator validation

Here we present LipidCreator, a software that fully supports targeted lipidomics assay development. LipidCreator offers a comprehensive framework to compute MS/MS fragment masses for over 60 lipid classes. LipidCreator provides all functionalities needed to define fragments, manage stable isotope...

2020-04-15 | MTBLS1382 | MetaboLights
UnknownPlant lipid transfer proteins: are we finally closing in on the roles of these enigmatic proteins?
Not available
S-EPMC6071764 | biostudies-literature
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