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MetabolomicsAutomated Label-free Quantification of Metabolites from Liquid Chromatography–Mass Spectrometry Data (Plasma)

Liquid chromatography coupled to mass spectrometry (LC-MS) has become a standard technology in metabolomics. In particular, label-free quantification based on LC-MS is easily amenable to large-scale studies and thus well suited to clinical metabolomics. Large-scale studies, however, require autom...

2015-12-16 | MTBLS234 | MetaboLights
ProteomicsSystemic effects of hemorrhagic snake venom metalloproteinases: untargeted peptidomics to explore the pathodegradome of plasma proteins
In this study we investigated the proteolysis of human plasma proteins by HF3, an hemorrhagic metalloproteinase from B. jararaca venom. For this purpose, approaches for the depletion of the most abundant proteins and for the enrichment of low abundant proteins of human plasma were used to minimize t...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027997 | Pride
Bothrops  snake venom  hemorrhagic factor 3 (hf3)  human plasma  degradome 
ProteomicsPlasma non-targeted peptidomics discovers potential biomarkers for major depressive disorder
Purpose There are great demands for identifying markers of major depressive disorder (MDD), which is a common mental illness with a prevalence of approximately 6%. Finding potential markers to aid MDD diagnosis is in high demand. Experimental design In this study, combination of the salt-out assiste...
ORGANISM(S): Homo sapiens (Human) 
2023-04-13 | PXD023009 | Pride
Peptidomics Major depressive disorder Biomarkers Plasma Diagnostic model 
MetabolomicsMaHPIC Experiment HuC - Metabolomics of plasma samples from human volunteers infected with Plasmodium vivax
Project Description:
The Malaria Host-Pathogen Interaction Center (MaHPIC) is a transdisciplinary malaria systems biology research program initially supported by an NIH/NIAID contract (HHSN272201200031C, 2012-2017; see http://w...
2018-06-19 | MTBLS665 | MetaboLights
ProteomicsReanalysis of the blood plasma and serum samples from healthy donors
Previously, we published a dataset of human blood plasma and serum samples of 10 healthy males and 10 healthy females, fractionated on a set of sorbents (cation exchange Toyopearl CM-650M, CM Bio-Gel A, SP Sephadex C-25 and anion exchange QAE Sephadex A-25) and analyzed by LC-MS/MS individually and ...
ORGANISM(S): Homo sapiens (Human) 
2024-06-14 | PXD027587 | Pride
Peptidomics Human microbiota Mass spectrometry Blood plasma and serum Healthy donors 
ProteomicsBlood plasma and serum samples of healthy donors fractionated on different chromatography sorbents
Blood as connective tissue potentially contain evidence of all processes occurring within the organism, at least in trace amounts. Because of their small size, peptides overcome cell membranes and epithelial barriers more freely than proteins. Among the peptides found in blood, there are both fragme...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-15 | MSV000081717 | MassIVE
ProteomicsMass spectrometry analysis of the blood plasma and serum samples from healthy donors
Previously, we published a dataset of human blood plasma and serum samples of 10 healthy males and 10 healthy females, fractionated on a set of sorbents (cation exchange Toyopearl CM-650M, CM Bio-Gel A, SP Sephadex C-25 and anion exchange QAE Sephadex A-25) and analyzed by LC-MS/MS individually and ...
ORGANISM(S): Homo sapiens (Human) 
2024-06-14 | PXD027552 | Pride
Peptidomics Mass spectrometry Blood plasma and serum Healthy donors 
ProteomicsOptimising sample preparation of the plasma peptidome
We further expanded on previous optimizations to isolate the plasma peptidome and compared various methods to maximize identifications with speed and ease. Previous studies have reported loss of polypeptides binding to high abundant proteins during depletion strategies. We hypothesized that rapid c...
ORGANISM(S): Homo sapiens (Human) 
2017-10-09 | PXD007191 | Pride
Peptidomics Plasma Sample preparation 
ProteomicsDe novo identification of the blood plasma and serum peptides from samples of healthy donors
Previously, we published a dataset of human blood plasma and serum samples of 10 healthy males and 10 healthy females, fractionated on a set of sorbents (cation exchange Toyopearl CM-650M, CM Bio-Gel A, SP Sephadex C-25 and anion exchange QAE Sephadex A-25) and analyzed by LC-MS/MS individually and ...
ORGANISM(S): Homo sapiens (Human) 
2024-06-14 | PXD027701 | Pride
Peptidomics Mass spectrometry Blood plasma and serum Healthy donors 
ProteomicsDysregulation of circulating protease activity in COVID-19-associated superinfection
Infection by SARS-CoV-2 and subsequent COVID-19 can cause viral sepsis and septic shock. Our past studies demonstrated that dysregulated systemic proteolysis is associated with the pathological mechanism in bacterial septic shock. Thus, here we perform shotgun proteomics and peptidomics analysis by ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD029181 | Pride
Peptidomics Proteomics Covid-19 Sepsis Proteolysis Enzymatic activity 
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