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TranscriptomicsRepression of arginase 2 expression in dendritic cells by microRNA-155 is critical for promoting T-cell proliferation
Microarray experiments were performed to compare the gene expression profiles exhibited by immature and activated bone-marrow (BM) derived conventional DCs (BM-cDCs) and plasmacytoid DCs (BM-pDCs) from WT and miR155-/- mice. (time points 0, 4 and 24 hours)
ORGANISM(S): Mus musculus 
2015-01-09 | E-MTAB-1527 | biostudies-arrayexpress
TranscriptomicsTissue-specific differentiation of a circulating CCR9- pDC-like common dendritic cell precursor
Committed precursors of conventional dendritic cells (pre-cDCs) derived from the common DC progenitor which differentiate into cDC subpopulations in peripheral tissues have been identified, but committed precursors for plasmacytoid DCs (pDCs) have not been found. Here we show that CDP-derived ‘CCR9-...
ORGANISM(S): Mus musculus 
2012-05-15 | E-GEOD-37996 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human plasmacytoid dentritic cells co-cultured with activated conventional dendritic cells
Two well-characterized blood dendritic cell populations, conventional (cDC) and plasmacytoid (pDC), exhibit multiple phenotypic, migratory and functional differences that suggest specialized and may be complementary and coordinated functions. To study this possible coordination, cDCs and pDCs from h...
ORGANISM(S): Homo sapiens 
2011-01-20 | E-MEXP-2555 | biostudies-arrayexpress
TranscriptomicsmicroRNA atlas of dendritic cell (DC) development
We determined the microRNA profile of conventional DCs, plasmacytoid DCs, in vitro derived conventional DCs, and DC precursors in the bone marrow. We then compared conventional DCs to plasmacytoid DCs, conventional DCs and in vitro conventional DCs. In addition, we used MDS analysis to compare all t...
ORGANISM(S): Mus musculus 
2015-05-05 | E-GEOD-57442 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of mouse splenic Dendritic cells subsets
We describe a novel subset of CD8+ DCs in lymphoid organs of naïve mice characterized by expression of the CX3CR1 chemokine receptor. CX3CR1+CD8+ DCs lack hallmarks of classical CD8+ DCs, including IL12 secretion, the capacity to cross-present antigen and their developmental independence of the tran...
ORGANISM(S): Mus musculus 
2010-07-28 | E-GEOD-23212 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human and mouse dendritic cell subsets
Dendritic cells (DCs) are a complex group of cells which play a critical role in vertebrate immunity. Spleen or lymph node resident DCs are subdivided into conventional DC (cDC) subsets (CD11b and CD8alpha in mouse; BDCA1 and BDCA3 in man) and plasmacytoid DCs (pDCs). It is currently unclear if thes...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9810 | biostudies-arrayexpress
TranscriptomicsTGF-β1 Accelerates Dendritic Cell Differentiation from Common Dendritic Cell Progenitors (CDPs) and Directs Subset Specification Towards Conventional Dendritic Cells
Dendritic cells (DCs) in lymphoid tissue comprise conventional DCs (cDCs) and plasmacytoid DCs (pDCs) that develop from common DC progenitors (CDPs). CDPs are Flt3+c-kitintM-CSFR+ and reside in bone marrow. Here we describe a two-step culture system that recapitulates DC development from c-kithiFlt3...
ORGANISM(S): Mus musculus 
2010-10-04 | E-GEOD-22432 | biostudies-arrayexpress
TranscriptomicsThe miR-126/VEGFR2 axis controls the innate response to pathogen-associated nucleic acids
microRNA-126 is a microRNA predominately expressed by endothelial cells and controls angiogenesis. Unexpectedly, we found that mice deficient in miR-126 have a major impairment in their innate response to pathogen-associated nucleic acids, as well as HIV, which results in more widespread cell infect...
ORGANISM(S): Mus musculus 
2013-11-24 | E-GEOD-51255 | biostudies-arrayexpress
ProteomicsProteomics of human dendritic cell subsets
We exploited label-free quantitative mass spectrometry to compare primary human blood Dendritic cells (DCs) subsets protein expression to identify new markers. Subsets distinguished are: Plasmacytoid DCs (pDC) and BDCA3+ and CD1c+ myeloid DCs and CD16+ monocytes. The dendritic cells were analyzed by...
ORGANISM(S): Homo sapiens (Human) 
2016-09-27 | PXD004678 | Pride
Cd1c+ myeloid dcs Dendritic cells Ms/ms (lc-ms/ms) Plasmacytoid dcs (pdcs) Lfq Bdca3+ Cd16+ monocytes 
TranscriptomicsTranscription profiling of mouse splenic dendritic cell subpopulations to characterize molecular differences among the cells.
To characterize differences between BALB/c splenic CD11cintB220+Gr1+ PDCs (plasmacytoid dendritic cells), CD11cintB220+CD49b+ IKDCs (interferon producing killer-dendritic cells), and CD11chighB220- cDCs (conventional dendritic cells), we performed gene expression profile analysis using Affymetrix ch...
ORGANISM(S): Mus musculus 
2007-11-01 | E-GEOD-3691 | biostudies-arrayexpress
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