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ProteomicsGenotype-dependent N-glycosylation and newly discovered O-glycosylation affecting HRG plasmin cleavage
Histidine-rich glycoprotein (HRG) is an abundant plasma glycoprotein with three reported N-glycosylation sites, which integrates many biological processes such as antiangiogenic activity, immune complex clearance and pathogen clearance. Importantly, the protein is known to have five genetic variants...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD044353 | Pride
Histidine-rich glycoprotein (hrg) O-glycosylation Glycoproteomics Plasmin cleavage N-glycosylation 
UnknownPlasmin and chymotrypsin have distinct preferences for channel activating cleavage sites in the γ subunit of the human epithelial sodium channel.
Not available
S-EPMC3457690 | biostudies-literature
UnknownProteolytic cleavage of human chromogranin a containing naturally occurring catestatin variants: differential processing at catestatin region by plasmin.
Not available
S-EPMC2219303 | biostudies-literature
UnknownAngiopoietin-like protein 4/8 complex-mediated plasmin generation leads to cleavage of the complex and restoration of LPL activity.
Not available
S-EPMC9963551 | biostudies-literature
UnknownCompetitive cleavage of SARS-CoV-2 spike protein and epithelial sodium channel by plasmin as a potential mechanism for COVID-19 infection.
Not available
S-EPMC9639761 | biostudies-literature
ProteomicsPlasminogen proteoform profiling
Plasminogen, the zymogen of plasmin, is a glycoprotein involved in fibrinolysis and a wide variety of other physiological processes. Plasminogen dysregulation has been implicated in a range of diseases. Classically, human plasminogen is categorized into two types based on the presence (type I) or ab...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2024-05-24 | PXD042225 | Pride
Plasminogen serum ptm 
UnknownProteolytic cleavage of extracellular α-synuclein by plasmin: implications for Parkinson disease.
Not available
S-EPMC3408156 | biostudies-literature
UnknownGenotype-dependent N-glycosylation and newly exposed O-glycosylation affect plasmin-induced cleavage of histidine-rich glycoprotein (HRG).
Not available
S-EPMC10882129 | biostudies-literature
UnknownEndoproteolysis of cellular prion protein by plasmin hinders propagation of prions.
Not available
S-EPMC9478470 | biostudies-literature
UnknownPlasmin modulates vascular endothelial growth factor-A-mediated angiogenesis during wound repair.
Not available
S-EPMC1606492 | biostudies-literature
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