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TranscriptomicsTranscription profiling of different developmental stages of Plasmodium falciparum to identify expression of non-coding RNAs
In summary, we present a systematic in silico screen for the conserved non-coding RNA structures by comparing the P. falciparum genome with seven other malaria species and describe 668 candidate RNA secondary structures. By combining microarray and northern data, we provide evidence for expression o...
ORGANISM(S): Plasmodium falciparum 
2007-08-23 | E-SGRP-8 | biostudies-arrayexpress
ProteomicsCircadian Control of the Response of Macrophages to Plasmodium spp.-Infected Red Blood Cells.
In this study, we sought to determine whether the intensity of the immune response to Plasmodium spp., the parasite causing malaria, depends on time of infection. For this, we considered the known existence of a circadian clock in immune cells which regulates several aspects of the immune response. ...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-26 | PXD049209 | Pride
Immune responses. Circadian rhythms Infected red blood cells Macrophages Plasmodium spp. 
ProteomicsValidation of Solvent Proteome Profiling for Antimalarial Drug Target Deconvolution
Malaria remains a global health threat, with rising drug resistance accelerating the urgent need for new therapeutics. Target elucidation is a critical step in antimalarial drug discovery, enabling a deeper understanding of the molecular mechanisms of action of both existing and novel compounds. Thi...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2025-11-25 | PXD071156 | Pride
Malaria  plasmodium falciparum  solvent-induced proteome profiling (spp)  drug target deconvolution  orbitrap astral ms  antimalarial compounds 
TranscriptomicsRapid activation of distinct members of multigene families in Plasmodium spp.
Variant antigens that are encoded by large multigene families play an important role in the adaptation and immune evasion of a wide range of pathogens. However, the study of their biological function is significantly hampered by the difficulty in controlling their expression in its cellular setting....
ORGANISM(S): Plasmodium yoelii 
2020-07-03 | GSE152162 | GEO
TranscriptomicsCapturing the dynamic RNA landscape of the malaria parasite P. falciparum
To date, total mRNA analysis throughout intraerythrocytic development of the malaria parasite, Plasmodium falciparum, has only revealed abundance profiles of each gene at a given time. Here, we establish a new methodology in Plasmodium falciparum that enables biosynthetic labeleing and capture of su...
ORGANISM(S): Plasmodium falciparum 
2015-09-04 | E-GEOD-72695 | biostudies-arrayexpress
TranscriptomicsRapid activation of distinct member of multigene families in Plasmodium spp.
The objective of this study is to provide a novel method to study multigene proteins in Plasmodium spp. The method is based on selection linked integration (SLI), which allows positive selection of genomic integration events. By targeting specific members of multigene families, parasites are being s...
ORGANISM(S): Plasmodium falciparum 
2019-03-12 | GSE128123 | GEO
GenomicsRapid activation of distinct members of multigene families in Plasmodium spp.
Rapid activation of distinct members of multigene families in Plasmodium spp.
PRJNA638463 | ENA
TranscriptomicsSingle cell data for plasmodium replication in mouse red blood cells
Hypoglycemia is a clinical hallmark of severe malaria, the often-lethal outcome of Plasmodium falciparum infection. Yet, the underlying mechanisms driving the pathogenesis of malaria-associated hypoglycemia remain poorly understood. Here we report that labile heme, an alarmin generated as a byproduc...
ORGANISM(S): Mus musculus 
2021-12-31 | E-MTAB-10939 | biostudies-arrayexpress
TranscriptomicsMouse liver transcriptome under the condition of fasting, Heme induction and plasmodium infection
Hypoglycemia is a clinical hallmark of severe malaria, the often-lethal outcome of Plasmodium falciparum infection. Yet, the underlying mechanisms driving the pathogenesis of malaria-associated hypoglycemia remain poorly understood. Here we report that labile heme, an alarmin generated as a byproduc...
ORGANISM(S): Mus musculus 
2021-12-31 | E-MTAB-10935 | biostudies-arrayexpress
ProteomicsPlasmodium spp. Glyceraldehyde 3-phosphate dehydrogenase: Diverse subcellular localization and multiple post-translational modifications
Glyceraldehyde 3-phosphate dehydrogenase (Gapdh), a glycolytic enzyme is known to be associated with multiple non-glycolytic functions. To examine the possibility of Plasmodium spp Gapdh having moonlighting functions, PfGapdh was cloned, overexpressed, purified to homogeneity and characterized. Poly...
ORGANISM(S): Plasmodium yoelii yoelii 
2018-01-08 | PXD002313 | Pride
Plasmodium spp.  glyceraldehyde 3-phopshate dehydrogenase  subcellular localization  post-translational modification  moonlighting functions  mass spectrometry 
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