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TranscriptomicsDGCR8 HITS-CLIP reveals novel functions for the Microprocessor (CLIP-seq)
The Drosha-DGCR8 complex (Microprocessor) is required for microRNA (miRNA) biogenesis. DGCR8 contains two double-stranded RNA binding motifs that recognize the RNA substrate, whereas Drosha functions as the endonuclease. We have used high-throughput sequencing of RNAs isolated by crosslinking immuno...
ORGANISM(S): Homo sapiens 
2012-07-15 | E-GEOD-39086 | biostudies-arrayexpress
TranscriptomicsAlternative poladenylation of tumor suppressor genes in small intestinal neuroendocrine tumors
The tumorigenesis of small intestinal neuroendocrine tumors (NETs) is poorly understood. Recent studies have associated alternative polyadenylation with proliferation, cell transformation and cancer. Polyadenylation is the process in which the pre-mRNA is cleaved at a polyA site and a polyA tail is ...
ORGANISM(S): Homo sapiens 
2014-04-10 | E-GEOD-56657 | biostudies-arrayexpress
TranscriptomicsDGCR8 acts as a novel adaptor for the exosome complex to degrade double-stranded structured RNAs
The Microprocessor complex (DGCR8/Drosha) is required for microRNA (miRNA) biogenesis but also binds and regulates the stability of several types of cellular RNAs. Of particular interest, DGCR8 controls the stability of mature small nucleolar RNA (snoRNA) transcripts independently of Drosha, suggest...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-73376 | biostudies-arrayexpress
TranscriptomicsDrosophila Imp iCLIP identifies an RNA assemblage co-ordinating F-actin formation
In this study, we employed a combination of RIP-seq and short- and long-wave iCLIP technologies to identify transcripts associated with cytoplasmic RNPs containing the RNA-binding protein Drosophila Imp. We also made a Imp knockdown vs luciferase control experiment. Two biological iCLIP-seq, as well...
ORGANISM(S): Drosophila melanogaster 
2015-05-27 | E-GEOD-62997 | biostudies-arrayexpress
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