Sort   by:  
 Page size 
MetabolomicsLactate controls cancer stemness and plasticity through epigenetic regulation.

Tumours arise from uncontrolled cell proliferation driven by mutations in genes that regulate stem cell renewal and differentiation. Intestinal tumours, however, retain some hierarchical organization, maintaining both cancer stem cells (CSCs) and cancer differentiated cells (CDCs). This heterogen...

2025-05-28 | MTBLS11849 | MetaboLights
MetabolomicsThe plasticity of the grapevine berry transcriptome
Vitis vinifera cultivar Corvina clone 48 berries were harvested from different vineyards, each located in one of the three most important wine production macro-areas of the Verona region: Bardolino, Valpolicella and Soave, on the basis of the site geographical coordinates. For each of the selected v...
2013-11-04 | MTBLS39 | MetaboLights
MetabolomicsSNAP25 inhibits glioma progression by regulating synapse plasticity via GLS-mediated glutaminolysis

INTRODUCTION: Neuronal activity regulated by synaptic communication exerts an important role in tumorigenesis and progression in brain tumors. Genes for soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) annotated with the function ‘vesicle’ about syn...

2021-08-12 | MTBLS2806 | MetaboLights
MetabolomicsEvolutionary novelty of Apolipoprotein D facilitates metabolic plasticity in lepidopteran wing

Understanding metabolic plasticity of animal evolution is a fundamental challenge in evolutionary biology. Owing to the diversification of insect wing morphology and dynamic energy requirements, the molecular adaptation mechanisms underlying the metabolic pathways in wing evolution remain largely...

2026-03-29 | MTBLS4308 | MetaboLights
MetabolomicsEvolutionary novelty of Apolipoprotein D facilitates metabolic plasticity in lepidopteran wings

Understanding metabolic plasticity of animal evolution is a fundamental challenge in evolutionary biology. Owing to the diversification of insect wing morphology and dynamic energy requirements, the molecular adaptation mechanisms underlying the metabolic pathways in wing evolution remain largely...

2026-03-29 | MTBLS11285 | MetaboLights
MetabolomicsFaecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

BACKGROUND: The gut-brain axis and the intestinal microbiota are emerging as key players in health and disease. Shifts in intestinal microbiota composition affect a variety of systems, however, evidence of their direct impact on cognitive functions is still lacking. We tested whe...

2021-12-17 | MTBLS1437 | MetaboLights
MetabolomicsCharacterization and Plasticity of the Metabolome in Peripheral Cells in Bipolar I Disorder
Not available
ORGANISM(S): Homo sapiens 
ST000361 | MetabolomicsWorkbench
MetabolomicsMetabolic plasticity of lipid storage and utilization governs fungal persister formation within macrophages
The ability of Candida glabrata to survive within macrophages creates a reservoir for recurrent infections and antifungal failure, yet the underlying mechanisms remain elusive. Here, using a host-mimicking in vitro evolution model, we identify asparagine synthetase (ASN2) as a critical genetic deter...
2026-04-22 | MTBLS14351 | MetaboLights
MetabolomicsAssessment of phenotypic trait plasticity in the oilseed Camelina sativa using integrated early-stage abiotic stress and field studies

Connecting the characterisation of juvenile (pre-anthesis) plant stress responses undertaken in controlled environments to field agronomic performance is a challenge. The oilseed crop Camelina sativa (camelina), with its innate resilience and plasticity, presents an opportunity to understand both...

2026-02-09 | MTBLS9839 | MetaboLights
ModelsLiX2019 - macrophage polarization and tumor cell plasticity
This model is based on: Computational Modeling of the Crosstalk Between Macrophage Polarization and Tumor Cell Plasticity in the Tumor Microenvironment. Abstract: Tumor microenvironments contain multiple cell types interacting among one another via different signaling pathways. Furthermore, both ca...
2019-09-23 | MODEL1909230002 | BioModels
Immuno-oncology 
Sort   by:  
 Page size