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TranscriptomicsRNA-seq expression profiling of NPM1mutated normal-AML with methylome status for HIST1 gene, i.e. H3K27me3 high (N=16) and H3K27me3 low (N=11). Transcriptome was done with Affymetrix HG-133+2.0 and Affymetrix Human Gene 2.0 ST microarrays
The epigenetic machinery is frequently altered in acute myeloid leukemia (AML). Focusing on cytogenetically normal (CN) AML, we previously described an abnormal H3K27me3 enrichment covering 70 kb on the HIST1 cluster (6.p22). Here, we further investigate the molecular, functional, and prognosis sign...
ORGANISM(S): Homo sapiens 
2020-08-25 | E-MTAB-6997 | biostudies-arrayexpress
TranscriptomicsPLZF acts as a regulator of cell-cycle genes, restricting hematopoietic stem cell proliferation and prevents hematopoietic stem cell aging.
To uncover gene programs that are regulated by PLZF in the early hematopoietic compartment, we performed micro array-based gene expression analysis of wild-type (WT) or PLZF-mutant (Zbtb16lu/lu) KSLs. DNA-microarrays were used to define and compare the transcriptional profiles of KSL cells isolated...
ORGANISM(S): Mus musculus 
2016-06-29 | E-MTAB-3682 | biostudies-arrayexpress
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