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UnknownEngineering editopes through programmable RNA editing toward tumor neoantigen generation
Not available
S-SCDT-10_1038-S44318-026-00870-5 | biostudies-other
TranscriptomicsIntegrated epigenetic and copy-number profiling identifies three clinically and biologically relevant groups of anaplastic glioma
The outcome of patients with anaplastic gliomas varies considerably depending on histology and single molecular markers such as codeletion of 1p/19q and mutations of the isocitrate dehydrogenase (IDH) gene. Whether a molecularly-based classification of anaplastic gliomas based on large scale genomic...
ORGANISM(S): Homo sapiens 
2014-06-06 | E-GEOD-58218 | biostudies-arrayexpress
TranscriptomicsSuppression of antitumor immunity by the oncometabolite 2-hydroxyglutarate
Isocitrate dehydrogenase (IDH) mutations, a hallmark of gliomagenesis, result in the production of the oncometabolite R-2-hydroxyglutarate (R-2-HG) which is thought to promote tumorigenesis via DNA methylation. Here we identify an additional immunosuppressive activity of R-2-HG: Tumor cell-derived R...
ORGANISM(S): Homo sapiens 
2016-07-27 | E-GEOD-84849 | biostudies-arrayexpress
ProteomicsThe B Cell Repertoire in Multiple Sclerosis Reveals Molecular Mimicry between EBNA1 and GlialCAM
This data set contains the mass spectrometry raw files for the paper The B Cell Repertoire in Multiple Sclerosis Reveals Molecular Mimicry between EBNA1 and GlialCAM. In multiple sclerosis (MS) intrathecal B lymphocytes are directly involved in inflammation and secrete oligoclonal immunoglobulin. Ho...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-02-11 | MSV000086842 | MassIVE
ProteomicsIdentification of tumor antigens among the HLA peptidomes of Glioblastoma tumors and plasma
Glioblastoma multiforme (GBM) is the most aggressive brain tumor with poor prognosis to most patients. Immunotherapy of GBM is a potentially beneficial treatment option, whose optimal implementation may depend on familiarity with tumor specific antigens, presented as HLA peptides by the GBM cells. F...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084343 | MassIVE
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