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After central nervous system injury, a rapid neuroinflammatory response is induced. This response can be both beneficial and detrimental to neuronal survival in the first few days and increase the risk for neurodegeneration if it persists. Semaphorin4B (Sema4B), a transmembrane protein primarily exp...
ORGANISM(S): Mus musculus 
2024-02-28 | GSE230069 | GEO
analysis of the immune and astrocytic cell fraction 12h after cortical injury in Sema4B knockout mice
The mechanisms involved in promoting metastasis of pancreatic ductal adenocarcinoma have yet to be elucidated. Here, we show that AnnexinA2 regulates the secretion of Semaphorin3D from pancreatic tumor cells allowing it to bind to its receptor PlexinD1 on the surface of the tumor cell, which induces...
ORGANISM(S): Mus musculus 
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