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GenomicsIdentification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells
In this work, we characterized the epigenomic integrity of 17 hiPSC lines derived from six different cell types with varied reprogramming efficiencies. We demonstrate that epigenetic aberrations are a general feature of the hiPSC state and are independent of the somatic cell source. Additionally, we...
ORGANISM(S): Homo sapiens 
2012-08-28 | E-GEOD-40372 | biostudies-arrayexpress
GenomicsCharacterization of genome-methylome interactions in 22 nuclear pedigrees
In this study, we investigated the interaction between CpG methylation and genetic polymorphisms by taking the advantage of the family structure in 22 nuclear pedigrees. We have identified CpG sites that exhibit heritable methylation patterns, among which the majority are SNPs ditrectly disrupting C...
ORGANISM(S): Homo sapiens 
2013-06-20 | E-GEOD-47614 | biostudies-arrayexpress
GenomicsModeling Fanconi Anemia pathogenesis and therapeutics using integration-free patient iPSCs
To elucidate the transcriptional and epigenetic alterations underlying the neurogenic defects of FA-NSCs, we conducted gene expression microarray analysis and global DNA methylation profiling. The gene expression pattern of gene-corrected NSCs (C-FA-NSCs) resembled that of control-NSCs but clustered...
ORGANISM(S): Homo sapiens 
2014-05-15 | E-GEOD-57685 | biostudies-arrayexpress
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