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TranscriptomicsMicroRNA expression profiling of human blood monocyte subsets highlights functional differences
Identification of micro-RNAs involved in regulating differential apoptosis and migration potential of human monocyte subsets Comparision between freshly isolated CD14++CD16- monocytes and CD14+CD16+ monocytes from healthy human blood
ORGANISM(S): Homo sapiens 
2015-03-07 | E-GEOD-52986 | biostudies-arrayexpress
TranscriptomicsHigh mitochondrial respiration and glycolytic capacity represent a metabolic phenotype of human tolerogenic dendritic cells
Human monocyte-derived dendritic cells (moDCs) have been used as an in vitro model for studying tolerance and immunity. However, the underlying metabolic states of tolerogenic (dexamethasone and vitamin D3-treated), immature and immunogenic (mature, LPS-treated) moDCs have not been completely charac...
ORGANISM(S): Homo sapiens 
2015-05-08 | E-GEOD-52894 | biostudies-arrayexpress
TranscriptomicsNFAT-dependent IL-2 and IL-23 produced by DC are key regulators of pathogenic (TH17-mediated lung inflammation)
Calcineurin/NFAT/IL-2 signaling pathway is activated in dendritic cells (DC) upon encounter of β glucan, the main component of the fungal cell wall, raising the question about the role of NFAT-regulated genes in DC biology in vivo. To directly assess the function of IL-2 secreted by DC, we analyzed...
ORGANISM(S): Mus musculus 
2015-12-21 | E-GEOD-58590 | biostudies-arrayexpress
TranscriptomicsTranscriptome profile of mouse lung dendritic cell subsets and macrophages.
Dendritic cell (DC) are critical initiators and regulators of immunity to pathogens, vaccines, tumors and tolerance to self. Mouse and human dendritic cells (DCs) are comprised of functionally specialized subsets, but precise interspecies correlation is currently incomplete and hampers the full tra...
ORGANISM(S): Mus musculus 
2013-05-29 | E-GEOD-46680 | biostudies-arrayexpress
TranscriptomicsDendritic cell-derived IL-2 promotes apoptosis of terminally mature cells via a novel autocrine signaling pathway
Dendritic cells (DCs) are crucial for sensing pathogens and triggering immune response. GM-CSF myeloid dendritic cells (GM-DCs) secrete several cytokines including IL-2 upon activation by pathogen associated molecular pattern (PAMP) ligands. DC IL-2 has been shown to be important for innate and adap...
ORGANISM(S): Mus musculus 
2015-05-21 | E-GEOD-58120 | biostudies-arrayexpress
TranscriptomicsTranscriptome profile of human dermal macrophages and monocyte-derived macrophages
DC, monocyte and macrophage networks are evolutionarily conserved but the distinct subsets have been difficult to distinguish due to shared overlapping phenotypic markers between the cells. Using transcriptome microarray profiling of human and mouse mononuclear phagocyte subsets, we have distinguish...
ORGANISM(S): Homo sapiens 
2014-10-15 | E-GEOD-60317 | biostudies-arrayexpress
TranscriptomicsExpression data from IgE+ and IgG1+ B lymphocytes in mice infected with Nippostrongylus brasiliensis
The mechanisms involved in the maintenance of memory IgE responses are poorly understood, and the role played by germinal center (GC) IgE cells in these memory responses is particularly unclear. IgE B-cell differentiation is characterized by a transient GC phase, a bias towards the plasma cell (PC) ...
ORGANISM(S): Mus musculus 
2013-10-31 | E-GEOD-49033 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiles of mouse and human monocyte and dendritic cell subsets (human data)
Dendritic cells (DCs) are critical in mediating immunity to pathogens, vaccines, tumors and tolerance to self. Significant progress has been made in the study of DC subsets in murine models but the translation of these findings to human DC immunobiology has not been fully realized. Murine splenic C...
ORGANISM(S): Homo sapiens 
2012-07-11 | E-GEOD-35457 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiles of mouse and human monocyte and dendritic cell subsets (mouse data)
Dendritic cells (DCs) are critical in mediating immunity to pathogens, vaccines, tumors and tolerance to self. Significant progress has been made in the study of DC subsets in murine models but the translation of these findings to human DC immunobiology has not been fully realized. Murine splenic C...
ORGANISM(S): Mus musculus 
2012-07-11 | E-GEOD-35458 | biostudies-arrayexpress
TranscriptomicsThe Transcriptional Stress Response of Candida albicans to Weak Organic Acids
Candida albicans is the most important fungal pathogen of humans, causing severe infections especially in nosocomial and immunocompromised settings. However, it is also the most prevalent fungus of the normal human microbiome, where it shares its habitat with hundreds of trillions of other microbia...
ORGANISM(S): Candida albicans 
2015-01-28 | E-GEOD-49310 | biostudies-arrayexpress
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