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MetabolomicsGABA regulates IL-1β production in macrophages
Neurotransmitters have been well-documented to determine immune cell fates; however, whether and how γ-amino butyric acid (GABA) shapes the function of innate immune cells is still obscure. Here, we demonstrated that GABA orchestrates macrophage maturation and inflammation. GABA treatment during mac...
2023-01-31 | MTBLS6337 | MetaboLights
TranscriptomicsmicroRNA expression profiling of polarized macrophages
microRNAs are small non-coding RNAs that regulate gene expression at a post-translational level, and play a crucial role in the development of cells of the immune system. Macrophages are essential for generating inflammatory reactions upon tissue damage and encountering of invading pathogens, yet mo...
ORGANISM(S): Homo Sapiens 
2014-01-14 | E-MTAB-1969 | biostudies-arrayexpress
TranscriptomicsExpression data from polarized macrophages: effect of p53
p53 is critically important in preventing oncogenesis but its role in non-cancer biology remains unclear. Macrophages exist as two subtypes (M1 and M2). Nutlin-3a (p53 activator) inhibits M2 gene expression and phenotype. p53 acts by suppressing transcription of c-Myc and thence regulates expressio...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-53321 | biostudies-arrayexpress
ProteomicsGS1 Cytokine Array Analysis of Primary Human Macrophages Polarized to M0, M1, M2, 14P-TAM, and 14P-RT TAM states
A comparative analysis of 20 analytes from matched primary macrophages polarized to various states was performed to characterize a novel polarization method and compare it to classically polarized M0, M1, and M2 macrophages. Macrophages polarized by the xenoline JX14P and its matched in vivo radiati...
ORGANISM(S): Homo sapiens 
2025-12-31 | E-MTAB-15227 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of M0, M1 and M2a macrophages after 7 days of culture
The relative contribution of polarized macrophages to the maintenance of tolerance is unknown. We examined their roles by in vivo adoptive transfer immunotherapy of M0, M1 and M2a macrophages as pre-treatment of colitis. In other experiments, M2a macrophages were used as pre-treatment or treatment o...
ORGANISM(S): Mus musculus 
2016-03-02 | E-GEOD-72518 | biostudies-arrayexpress
ProteomicsQuantitative proteomic analysis of polarized macrophages
In this study, by using two classical macrophage cell models, RAW264.7 cell line from mouse and THP-1 cell line from human, combined with the applications of two classical stimulation methods for inducing classical activated (M1) and alternatively activated macrophages (M2) from the monocytes of bot...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-06-18 | PXD019800 | Pride
Macrophage Polarization Lc-ms/ms 
TranscriptomicsCXCL4 induces a unique transcriptome in monocyte-derived macrophages
Human blood monocytes were differentiated over six days with either 100 ng/ml M-CSF or 1 umol/l CXCL4 In atherosclerotic arteries, blood monocytes differentiate to macrophages in the presence of growth factors like macrophage colony-stimulation factor (MCSF) and chemokines like platelet factor 4 (CX...
ORGANISM(S): Homo sapiens 
2010-03-07 | E-GEOD-20484 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of M1 and M2 polarized macrophages with CNI-1493 treatment
Analysis of the effects of CNI-1493 treatment on M1 and M2 polarized macrophages. The purpose of this microarray is to identify genes that may be differentially expressed in M1 or M2 macrophages after treatment with CNI-1493. CNI-1493 is a known inhibitor of M1 macrophages but details of its molecul...
ORGANISM(S): Homo sapiens 
2015-03-12 | E-GEOD-66805 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocytes cultured in the presence of M-CSF for 7 days and polarized to M1 or M2 cells to characterize human monocyte-to-macrophage differentiation and polarization
Monocytes mature to macrophages in the presence of the lineage determining cytokine M-CSF. They can be further polarized into M1 or M2 macrophages with distinct functional properties. We used microarrays to detail the global programme of gene expression underlying macrophage maturation and polarizat...
ORGANISM(S): Homo sapiens 
2007-11-02 | E-GEOD-5099 | biostudies-arrayexpress
TranscriptomicsMicroarray of non-polarized and M1- and M2-polarized canine macrophages in vitro
Unstimulated (M0), M1-polarized (GM-CSF, LPS, IFNγ-stimulated), and M2-polarized (M-CSF, IL-4-stimulated) canine blood-derived macrophages were generated in vitro and investigated for differences in their transcriptome to create a basis for future investigations upon the role of macrophage polariza...
ORGANISM(S): Canis lupus familiaris 
2017-08-10 | E-MTAB-5458 | biostudies-arrayexpress
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